NDLI: Effect of Codonopsis lanceolata with Steamed and Fermented Process on Scopolamine-Induced Memory Impairment in Mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weon, Jin Bae Yun, Bo-Ra Lee, Jiwoo Eom, Min Rye Ko, Hyun-Jeong Kim, Ji Seon Lee, Hyeon Yong Park, Dong-Sik Chung, Hee-Chul Chung, Jae Youn Ma, Choong Je
Description	Author Affiliation: Weon JB ( Department of Medical Biomaterials Engineering, College of Biomedical Science.)
Abstract	Codonopsis lanceolata (Campanulaceae) traditionally have been used as a tonic and to treat patients with lung abscesses. Recently, it was proposed that the extract and some compounds isolated from C. lanceolata reversed scopolamine-induced memory and learning deficits. The purpose of this study was to evaluate the improvement of cognitive enhancing effect of C. lanceolata by steam and fermentation process in scopolamine-induced memory impairment mice models by passive avoidance test and Morris water maze test. The extract of C. lanceolata or the extract of steamed and fermented C. lanceolata (SFCE) was orally administered to male mice at the doses of 100 and 300 mg/kg body weight. As a result, mice treated with steamed and fermented C. lanceolata extract (SFCE) (300 mg/kg body weight, p.o.) showed shorter escape latencies than those with C. lanceolata extract or the scopolamine-administered group in Morris water maze test. Also, it exerted longer step-through latency time than scopolamine treated group in passive avoidance test. Furthermore, neuroprotective effect of SFCE on glutamate-induced cytotoxicity was assessed in HT22 cells. Only SFCE-treated cells showed significant protection at 500 µg/ml. Interestingly, steamed C. lanceolata with fermentation contained more phenolic acid including gallic acid and vanillic acid than original C. lanceolata. Collectively, these results suggest that steam and fermentation process of C. lanceolata increased cognitive enhancing activity related to the memory processes and neuroprotective effect than original C. lanceolata.
File Format	HTM / HTML
ISSN	19769148
e-ISSN	20054483
DOI	10.4062/biomolther.2013.055
Journal	Biomolecules & Therapeutics
Issue Number	5
Volume Number	21
Language	English
Publisher	The Korean Society of Applied Pharmacology
Publisher Date	2013-09-30
Publisher Place	Korea (South)
Access Restriction	Open
Subject Keyword	Discipline Pharmacology
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Biochemistry Molecular Medicine Pharmacology

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