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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miyazawa, Takayuki |
| Description | Country affiliation: Japan Author Affiliation: Miyazawa T ( Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan. takavet@gmail.com) |
| Abstract | Retroviruses are classified as exogenous or endogenous according to their mode of transmission. Generally, endogenous retroviruses (ERVs) are not pathogenic in their original hosts; however, some ERVs induce diseases. In humans, a novel gammaretrovirus was discovered in patients with prostate cancer or chronic fatigue syndrome. This virus was closely related to xenotropic murine leukemia virus (X-MLV) and designated as xenotropic murine leukemia virus-related virus (XMRV). The origin and transmission route of XMRV are still unknown at present; however, XMRV may be derived from ERVs of rodents because X-MLVs are ERVs of inbred and wild mice. Many live attenuated vaccines for animals are manufactured by using cell lines from animals, which are known to produce infectious ERVs; however, the risks of infection by ERVs from xenospecies through vaccination have been ignored. This brief review gives an overview of ERVs in cats, the potential risks of ERV infection by vaccination, the biological characteristics of RD-114 virus (a feline ERV), which possibly contaminates vaccines for companion animals, and the methods for detection of infectious RD-114 virus. |
| File Format | HTM / HTML |
| ISSN | 10451056 |
| Issue Number | 3 |
| Volume Number | 38 |
| e-ISSN | 10958320 |
| Journal | Biologicals |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Cats Virology Endogenous Retroviruses Genetics Retroviridae Viral Vaccines Standards Animals Cell Line, Tumor Drug Contamination Mice Immunology Risk Assessment Vaccination Veterinary Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmacology Bioengineering Applied Microbiology and Biotechnology Biotechnology |
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