NDLI: Stabilization of Ephedrine Alkaloid Content in Ephedra sinica by Selective Breeding and Stolon Propagation.

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Stabilization of Ephedrine Alkaloid Content in Ephedra sinica by Selective Breeding and Stolon Propagation.

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Stabilization of Ephedrine Alkaloid Content in Ephedra sinica by Selective Breeding and Stolon Propagation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hiyama, Hajime Ozawa, Aya Kumazawa, Hiroaki Takeda, Osami
Description	Author Affiliation: Hiyama H ( Botanical Raw Materials Research Laboratories, Tsumura & Co.)
Abstract	The Ephedra herb, which has been used in Kampo medicines, originates from terrestrial stems of Ephedra species. It is important to establish cultivation methods and cultivars to secure a stable supply of the Ephedra herb that would meet the quality standards for the ephedrine alkaloids content. In this study, we first grew Ephedra sinica plants derived from seeds in the field for 5 years. Then, for selective breeding of cultivars that could meet the quality standards for the ephedrine alkaloids content, we measured the content of total alkaloids (TAs), ephedrine (Eph), and pseudoephedrine (PEph) in individual plants derived from seedlings and grown for 4 years in the field. The range of the TA content in each individual plant was narrower than that among individual plants grown in the field. Therefore, individual plants were selected according to their TA content, Eph/PEph ratio, and stolon-formation capability. The selected individuals were propagated using stolons, and their TA content was studied for 2 years. In the second year, the TA content in terrestrial stems derived from stolons of the selected individuals was as high as that of their parents. Therefore, it was confirmed that the selected individuals that were propagated using stolons could produce TA reproducibly. This study suggested that selective breeding using stolon propagation is effective for stabilizing Ephedra herb TA content.
File Format	HTM / HTML
ISSN	09186158
e-ISSN	13475215
Journal	Biological & Pharmaceutical Bulletin
Issue Number	1
Volume Number	40
Language	English
Publisher	The Pharmaceutical Society of Japan J-STAGE
Publisher Date	2017-01-01
Publisher Place	Japan
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Discipline Pharmacology Alkaloids Metabolism Ephedra Sinica Ephedrine Pseudoephedrine Plant Breeding
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmacology Pharmaceutical Science

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