NDLI: Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.

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Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Arslan, Serdal
Spatial Coverage	Turkey
Description	Country affiliation: Turkey Author Affiliation: Arslan S ( Department of Molecular Biology and Genetics, Cumhuriyet University, Sivas, Turkey. arserdal@yahoo.com)
Abstract	Sulfotransferases (SULTs) play a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds. SULTs are genetically polymorphic enzymes; to date, 12 human cytosolic SULT isoforms have been identified. This study investigated SULT1A1 and SULT1A2 gene polymorphism using a PCR-RFLP method (n = 303). The frequency of the SULT1A11 allele was 76.2% and SULT1A12 was 23.8%. The SULT1A13 allele could not be identified. The SULT1A2 frequencies were 69.2% (SULT1A21), 18.3% (SULT1A22), and 12.5% (SULT1A23). The SULT1A1 and SULT1A2 loci were in Hardy-Weinberg equilibrium (SULT1A1 χ² = 0.58, P = 0.44; SULT1A2 χ² = 7.28, P = 0.06). Linkage analysis indicated a close linkage between these two genes (χ² = 5.31, P < 0.01); therefore, the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected. Additionally, a strongly positive linkage was detected between SULT1A12 and SULT1A22 alleles in this population (D' = 0.79, χ² = 33.33).
File Format	HTM / HTML
ISSN	00062928
Issue Number	11-12
Volume Number	48
e-ISSN	15734927
Journal	Biochemical Genetics
Language	English
Publisher	Springer
Publisher Date	2010-12-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Arylsulfotransferase Genetics Gene Frequency Isoenzymes Linkage Disequilibrium Polymorphism, Genetic Sulfotransferases Blood Base Sequence Humans Molecular Sequence Data Mutation Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Turkey Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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Genetic Polymorphisms of Sulfotransferases (SULT1A1 and SULT1A2) in a Turkish Population

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Genetic Polymorphisms of Sulfotransferases (SULT1A1 and SULT1A2) in a Turkish Population

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Genetic polymorphisms of sulfotransferases (SULT1A1 and SULT1A2) in a Turkish population.