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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Antunes, Ophélie Filippi, Jérôme Hébuterne, Xavier Peyrin-Biroulet, Laurent |
| Description | Author Affiliation: Antunes O ( Department of Hepato-Gastroenterology and Clinical Nutrition, Nice Teaching Hospital (CHU), 06200 Nice, France. Electronic address: antunes.o@chu-nice.fr.); Filippi J ( Department of Hepato-Gastroenterology and Clinical Nutrition, Nice Teaching Hospital (CHU), 06200 Nice, France. Electronic address: filippi.j@chu-nice.fr.); Hébuterne X ( Department of Hepato-Gastroenterology and Clinical Nutrition, Nice Teaching Hospital (CHU), 06200 Nice, France. Electronic address: hebuterne.x@chu-nice.fr.); Peyrin-Biroulet L ( Inserm U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Université de Lorraine, Vandoeuvre-lès-Nancy, France. Electronic address: peyrinbiroulet@gmail.com.) |
| Abstract | Crohn's disease is a chronic, progressive and disabling condition. New therapeutic goals have emerged in Crohn's disease such as the need to look beyond symptoms by achieving mucosal healing that is known to be associated with better outcomes. Anti-TNF (Tumour Necrosis Factor) therapy is the most potent drug class to induce and maintain mucosal healing in Crohn's disease. Recent evidence indicates that the efficacy profile of thiopurines has been overestimated while the increased risk of malignancies (lymphoma, non-melanoma skin cancers, myeloid disorders) has been underestimated. Methotrexate is well-tolerated, but its potential for disease modification is unknown. Achieving mucosal healing in patients with early Crohn's disease might be the best way to change disease course and patients' life. In 2014, anti-TNF treatment should be the first-line therapy in patients with Crohn's disease who suffer from severe and/or complicated disease and in those with poor prognostic factors. In the remaining patients, a rapid step-up approach based on a tight monitoring is recommended. |
| File Format | HTM / HTML |
| ISSN | 15216918 |
| Issue Number | 3 |
| Volume Number | 28 |
| e-ISSN | 15321916 |
| Journal | Best Practice & Research Clinical Gastroenterology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Algorithms Crohn Disease Drug Therapy Immunosuppressive Agents Therapeutic Use 6-mercaptopurine Analogs & Derivatives Adalimumab Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Certolizumab Pegol Pathology Humans Immunoglobulin Fab Fragments Infliximab Methotrexate Polyethylene Glycols Practice Guidelines As Topic Tumor Necrosis Factor-alpha Antagonists & Inhibitors Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
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