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Year: 2012 Volume: 11

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Tau protein kinases: involvement in Alzheimer's disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martin, Ludovic Latypova, Xenia Wilson, Cornelia M. Magnaudeix, Amandine Perrin, Marie-Laure Yardin, Catherine Terro, Faraj
Description	Country affiliation: France Author Affiliation: Martin L ( Groupe de Neurobiologie Cellulaire - Homéostasie cellulaire et pathologies, Faculté de Médecine, Limoges, France. lmartin.phd@gmail.com)
Abstract	Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby might contribute to tau aggregation. Thus, understanding the regulation modes of tau phosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates in order to elaborate protection strategies to cope with these lesions in Alzheimer's disease. Among the possible and specific interventions that reverse tau phosphorylation is the inhibition of certain tau kinases. Here, we extensively reviewed tau protein kinases, their physiological roles and regulation, their involvement in tau phosphorylation and their relevance to AD. We also reviewed the most common inhibitory compounds acting on each tau kinase.
File Format	HTM / HTML
ISSN	15681637
Issue Number	1
Volume Number	12
e-ISSN	18729649
Journal	Ageing Research Reviews
Language	English
Publisher	Elsevier
Publisher Date	2013-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Geriatrics Alzheimer Disease Enzymology Glycogen Synthase Kinase 3 Physiology Tau Proteins Genetics Metabolism Animals Humans Phosphorylation Proline-directed Protein Kinases Protein-tyrosine Kinases Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Neurology Aging Biochemistry Molecular Biology Biotechnology

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