NDLI: The roles of the skeleton and phosphorus in the CKD mineral bone disorder.

Please wait, while we are loading the content...

The roles of the skeleton and phosphorus in the CKD mineral bone disorder.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hruska, Keith A. Mathew, Suresh
Description	Country affiliation: United States Author Affiliation: Hruska KA ( Division of Pediatric Nephrology, Department of Pediatrics, Washington University, St. Louis, MO 63110, USA. hruska_k@kids.wustl.edu)
Abstract	The CKD mineral bone disorder is a new term coined to describe the multiorgan system failure that is a major component of the excess cardiovascular mortality and morbidity complicating decreased kidney function. This syndrome embodies new discoveries of organ-to-organ communication including the skeletal hormone fibroblast growth factor-23 (FGF-23), which signals the status of skeletal mineral deposition to the kidney. The CKD mineral bone disorder begins with mild decreases in kidney function (stage 2 CKD) affecting the skeleton, as marked by increased FGF-23 secretion. At this stage, the stimulation of cardiovascular risk has begun and the increases in FGF-23 levels are strongly predictive of cardiovascular events. Later in CKD, hyperphosphatemia ensues when FGF-23 and hyperparathyroidism are no longer sufficient to maintain phosphate excretion. Hyperphosphatemia has been shown to be a direct stimulus to several cell types including vascular smooth muscle cells migrating to the neointima of atherosclerotic plaques. Phosphorus stimulates FGF-23 secretion by osteocytes and expression of the osteoblastic transcriptome, thereby increasing extracellular matrix mineralization in atherosclerotic plaques, hypertrophic cartilage, and skeletal osteoblast surfaces. In CKD, the skeleton positively contributes to hyperphosphatemia through excess bone resorption and inhibition of matrix mineralization. Thus, through the action of phosphorus, FGF-23, and other newly discovered skeletal hormones, such as osteocalcin, the skeleton plays an important role in the occurrence of cardiovascular morbidity in CKD.
File Format	HTM / HTML
ISSN	15485595
e-ISSN	15485609
DOI	10.1053/j.ackd.2011.01.001
Journal	Advances in Chronic Kidney Disease
Issue Number	2
Volume Number	18
Language	English
Publisher	Elsevier
Publisher Date	2011-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Nephrology Bone Diseases, Metabolic Metabolism Bone And Bones Phosphates Renal Insufficiency, Chronic Physiopathology Cardiovascular Diseases Renal Osteodystrophy Fibroblast Growth Factors Hyperphosphatemia Etiology Ossification, Heterotopic Syndrome Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Nephrology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Women and CKD-mineral and bone disorder.

Chronic kidney disease: mineral and bone disorder in children.

Derangements in phosphate metabolism in chronic kidney diseases/endstage renal disease: therapeutic considerations.

CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder.

Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD).

Phosphate enters the syzygy.

The flux of phosphate: rapid evolution.

Evaluating bone quality in patients with chronic kidney disease.

Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism.

The roles of the skeleton and phosphorus in the CKD mineral bone disorder.

Similar Documents

Women and CKD-mineral and bone disorder.

Chronic kidney disease: mineral and bone disorder in children.

Derangements in phosphate metabolism in chronic kidney diseases/endstage renal disease: therapeutic considerations.

CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder.

Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD).

Phosphate enters the syzygy.

The flux of phosphate: rapid evolution.

Evaluating bone quality in patients with chronic kidney disease.

Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism.

The roles of the skeleton and phosphorus in the CKD mineral bone disorder.