NDLI: Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Almon, Richard R. Yang, Eric Lai, William Androulakis, Ioannis P. Ghimbovschi, Svetlana Hoffman, Eric P. Jusko, William J. Dubois, Debra C.
Description	Country affiliation: United States Author Affiliation: Almon RR ( Dept. of Biological Sciences, State Univ. of New York at Buffalo, Buffalo, NY 14260, USA.)
Abstract	The existence and maintenance of biological rhythms linked to the 24-h light-dark cycle are essential to the health and functioning of an organism. Although much is known concerning central clock mechanisms, much less is known about control in peripheral tissues. In this study, circadian regulation of gene expression was examined in rat skeletal muscle. A rich time series involving 54 animals euthanized at 18 distinct time points within the 24-h cycle was performed, and mRNA expression in gastrocnemius muscles was examined using Affymetrix gene arrays. Data mining identified 109 genes that were expressed rhythmically, which could be grouped into eight distinct temporal clusters within the 24-h cycle. These genes were placed into 11 functional categories, which were examined within the context of temporal expression. Transcription factors involved in the regulation of central rhythms were examined, and eight were found to be rhythmically expressed in muscle. Because endogenous glucocorticoids are a major effector of circadian rhythms, genes identified here were compared with those identified in previous studies as glucocorticoid regulated. Of the 109 genes identified here as circadian rhythm regulated, only 55 were also glucocorticoid regulated. Examination of transcription factors involved in circadian control suggests that corticosterone may be the initiator of their rhythmic expression patterns in skeletal muscle.
File Format	HTM / HTML
ISSN	03636119
e-ISSN	15221490
DOI	10.1152/ajpregu.90399.2008
Journal	AJP: Regulatory, Integrative and Comparative Physiology
Issue Number	4
Volume Number	295
Language	English
Publisher	American Physiological Society
Publisher Date	2008-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Physiology Circadian Rhythm Physiology Gene Expression Regulation Drug Effects Glucocorticoids Pharmacology Muscle, Skeletal Animals Cluster Analysis Corticosterone Blood Gene Expression Profiling Methylprednisolone Muscle Proteins Genetics Metabolism Oligonucleotide Array Sequence Analysis Photoperiod Rats, Wistar Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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