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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Barratt, Kristen S. Glanville-Jones, Hannah C. Arkell, Ruth M. |
| Description | Country affiliation: Australia Author Affiliation: Barratt KS ( Early Mammalian Development Laboratory, Research School of Biology, Evolution, Ecology and Genetics, The Australian National University, Canberra, ACT 0200, Australia.) |
| Abstract | The first molecular herald of organ asymmetry during murine embryogenesis is found at the periphery of the node in early-somite stage embryos. Asymmetric gene expression and calcium accumulation at the node occurs in response to a left-ward flow of extracellular fluid across the node, generated by motile cilia within the pit of the node and likely sensed by immotile cilia in the periphery of the node. The ciliation of node cells is controlled by a cascade of node-restricted transcription factor activity during mid-late gastrulation. Mutation of the murine Zic2 transcription factor is associated with random cardiac situs and a loss of asymmetric gene expression at the early-somite node and in the lateral plate. Zic2 is not expressed in these regions but is transiently expressed in the mid-late gastrula node at the time of ciliogenesis. The cilia of the node are overtly abnormal in Zic2 mutant embryos being dysmorphic and short relative to wild-type littermates. The expression of the Noto, Rfx3, and Foxj1 transcription factors known to regulate ciliogenesis is greatly depleted in the mid-gastrula node of mutants, as is the expression of the Pkd1l1 gene required for cilia function. Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation. |
| File Format | HTM / HTML |
| ISSN | 1526954X |
| Issue Number | 6 |
| Volume Number | 52 |
| e-ISSN | 1526968X |
| Journal | genesis |
| Language | English |
| Publisher | Wiley-Liss |
| Publisher Date | 2014-06-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Genetics Discipline Developmental Biology Discipline Embryology Cilia Genetics Heart Conduction System Embryology Metabolism Heart Organogenesis Physiology Transcription Factors Animals Body Patterning Embryonic Development Endoderm Gene Expression Regulation, Developmental Mice Mice, Knockout Morphogenesis Mutation Nodal Protein Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Medicine Endocrinology |
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