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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ha, Seung Yeon Ahn, Jungsuk Roh, Mee Sook Han, Joungho Lee, Jae Jun Lee, Boin Yim, Jun |
| Description | Responsible library: WPRO |
| Abstract | BACKGROUND: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. METHODS: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. RESULTS: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. CONCLUSIONS: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001). |
| File Format | HTM / HTML |
| ISSN | 17381843 |
| e-ISSN | 20928920 |
| Journal | The Korean Journal of Pathology |
| Issue Number | 3 |
| Volume Number | 47 |
| Language | English |
| Publisher | The Korean Society of Pathologists;Korean Society for Cytopathology |
| Publisher Date | 2013-01-01 |
| Publisher Place | Korea (South) |
| Access Restriction | Open |
| Subject Keyword | Discipline Pathology Adenocarcinoma Carcinoma, Non-small-cell Lung Chromatin Lung Lymphoma Mucins Phosphotransferases Original Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine |
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