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Year: 2011 Volume: 55 Issue: 7-9

Year: 2011 Volume: 55 Issue: 10-12

Year: 2010 Volume: 54

Year: 2009 Volume: 53

Paracrine regulation of angiogenesis by different cell types in the aorta ring model.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nicosia, Roberto F. Zorzi, Penelope Ligresti, Giovanni Morishita, Ann Aplin, Alfred C.
Description	Country affiliation: United States Author Affiliation: Nicosia RF ( Veterans Administration Puget Sound Health Care System, Seattle, WA, USA. roberto.nicosia@va.gov)
Abstract	The development of blood vessels during angiogenesis is the result of paracrine interactions between tube-forming endothelial cells and angiogenic factor-producing nonendothelial cells. This process can be reproduced and studied under chemically defined culture conditions by culturing vascular explants in three-dimensional gels of extracellular matrix. Rings of rat or mouse aorta cultured in collagen, fibrin or basement membrane gels produce angiogenic outgrowths composed of a mixed population of endothelial cells and nonendothelial cells. Aortic angiogenesis is regulated by endogenous angiogenic factors, inflammatory cytokines, chemokines, extracellular matrix molecules, and proteolytic enzymes produced by cells of the vessel wall in response to the injury of the dissection procedure. In this paper, we review how macrophages, mural cells and fibroblasts regulate different stages of the angiogenic process, from the formation of immature endothelial sprouts to the reabsorption of the neovessels. We also describe how aortic cultures can be used to study interactions between angiogenic outgrowths and nonvascular cell types such as bone marrow macrophages, platelets or cancer cells. Morphologic, genetic and functional studies of this model have provided invaluable information on how vessels form, mature, interact with nonvascular cell types, and are eventually reabsorbed. Further analysis of the paracrine cross-talk between aortic endothelial and nonendothelial cells is likely to provide new insights into the angiogenic process and its key mechanisms.
File Format	HTM / HTML
ISSN	02146282
e-ISSN	16963547
Journal	The International Journal of Developmental Biology
Issue Number	4-5
Volume Number	55
Language	English
Publisher	University of the Basque Country Press
Publisher Date	2011-01-01
Publisher Place	Spain
Access Restriction	Open
Subject Keyword	Discipline Embryology Discipline Biology Aorta Cytology Growth & Development Neovascularization, Physiologic Physiology Paracrine Communication Animals Injuries Blood Platelets Endothelial Cells Fibroblasts Macrophages Mice Microvessels Neoplasms, Experimental Blood Supply Neovascularization, Pathologic Physiopathology Tissue Culture Techniques Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Embryology

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