NDLI: Calnexin is required for zebrafish posterior lateral line development.

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Calnexin is required for zebrafish posterior lateral line development.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hung, I-Chen Cherng, Bor-Wei Hsu, Wen-Ming Lee, Shyh-Jye
Description	Author Affiliation: Hung IC ( Institute of Zoology, National Taiwan University, Taipei, Taiwan, ROC.)
Abstract	The lateral line is a mechanosensory system in fish and amphibians to detect local water flow and pressure. Development of the posterior lateral line (PLL) originates from the migrating PLL primordium (PLLP). The PLLP deposits neuromasts on the trunk during migration to the tail. Molecular dissection revealed that PLL development is associated with genes mediating cell adhesion, morphogenesis, neurogenesis and development, but the regulatory signaling network is far from completion. To further investigate candidate regulatory genes for lateral line development, we found using whole-mount in situ hybridization that calnexin, an endoplasmic reticular (ER) calcium-binding protein gene, is expressed in PLL neuromasts. Knockdown of calnexin using antisense morpholino oligonucleotides resulted in a dose-dependent reduction in neuromasts and hair cells of the PLL. Using a transgenic claudin b:gfp line, we observed a notably reduced PLLP size, but no significant migration defect in calnexin morphants. Finally, we discovered that the reduced PLLP is associated with a reduction in cell proliferation and an increase in ER stress-dependent apoptosis. These results suggest that calnexin is essential for neuromast formation during lateral line development in the zebrafish.
File Format	HTM / HTML
ISSN	02146282
e-ISSN	16963547
Journal	The International Journal of Developmental Biology
Issue Number	5
Volume Number	57
Language	English
Publisher	University of the Basque Country Press
Publisher Date	2013-01-01
Publisher Place	Spain
Access Restriction	Open
Subject Keyword	Discipline Embryology Discipline Biology Calnexin Genetics Embryo, Nonmammalian Metabolism Lateral Line System Zebrafish Amino Acid Sequence Animals Animals, Genetically Modified Apoptosis Classification Cell Proliferation Cytology Embryology Gene Expression Regulation, Developmental Gene Knockdown Techniques Green Fluorescent Proteins In Situ Hybridization Microscopy, Confocal Molecular Sequence Data Phylogeny Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Time Factors Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Embryology

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