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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ozkokeli, Mehmet Es, Mehmet Ugur Filizcan, Ugur Ugurlucan, Murat Sasmazel, Ahmet Tataroglu, Cenk |
| Description | Country affiliation: Turkey Author Affiliation: Ozkokeli M ( Department of Cardiovascular Surgery, Kartal Kosuyolu Research and Training Hospital, Istanbul, Turkey.) |
| Abstract | BACKGROUND: Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model. METHODS: Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation. RESULTS: Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (P < .05). CONCLUSION: IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear. |
| File Format | HTM / HTML |
| ISSN | 10983511 |
| Issue Number | 5 |
| Volume Number | 14 |
| e-ISSN | 15226662 |
| Journal | The Heart Surgery Forum |
| Language | English |
| Publisher | Forum Multimedia Publishing |
| Publisher Date | 2011-10-01 |
| Publisher Place | United States |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline General Surgery Discipline Cardiology Ischemic Preconditioning, Myocardial Paraplegia Prevention & Control Spinal Cord Ischemia Complications Animals Disease Models, Animal Male Nervous System Diseases Etiology Rabbits Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery Cardiology and Cardiovascular Medicine |
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