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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Namera, Akira Makita, Ryosuke Saruwatari, Tatsuro Hatano, Aiko Shiraishi, Hiroaki Nagao, Masataka |
| Description | Country affiliation: Japan Author Affiliation: Namera A ( Department of Forensic Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. namera@hiroshima-u.ac.jp) |
| Abstract | A 52-year-old woman was found dead on the floor of the living room on the first floor of a house, which belonged to the man with whom she shared the house. On visiting the site, her clothes were found to be undisturbed. Packages of flunitrazepam (Silece, 2 mg/tablet) and triazolam (Halcion, 0.25 mg/tablet) were found strewn around the victim. Toxicological analysis was performed, and the concentrations of flunitrazepam, triazolam, and their metabolites in the victim's blood and urine were measured by high-performance liquid chromatography coupled with photodiode array and mass spectrometry. A high blood concentration of 7-aminoflunitrazepam was detected (1,270 ng/g), and further metabolites such as 7-acetamidoflunitrazepam, 7-acetamidodesmethylflunitrazepam, and 7-aminodesmethylflunitrazepam were detected in the blood and urine samples. In addition, 4-hydroxytriazolam and -hydroxytriazolam were detected in her urine at a concentration of 950 and 12,100 ng/mL, respectively.On the basis of the autopsy findings and toxicology results of high concentrations of both flunitrazepam and triazolam derivatives, the cause of death was determined to be acute intoxication from flunitrazepam and triazolam. |
| File Format | HTM / HTML |
| ISSN | 01957910 |
| Issue Number | 4 |
| Volume Number | 33 |
| e-ISSN | 1533404X |
| Journal | The American Journal of Forensic Medicine and Pathology |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2012-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Jurisprudence Discipline Forensic Sciences Discipline Pathology Anti-anxiety Agents Poisoning Flunitrazepam Analogs & Derivatives Triazolam Blood Urine Chromatography, High Pressure Liquid Drug Overdose Female Forensic Toxicology Humans Mass Spectrometry Middle Aged Analysis Case Reports Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Pathology and Forensic Medicine |
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