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Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smith, Gwenn S. Ma, Yilong Dhawan, Vijay Chaly, Thomas Eidelberg, David
Description	Country affiliation: United States Author Affiliation: Smith GS ( Department of Psychiatry Research, the Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA. gwenn_smith@camh.net)
Abstract	The effect of a pharmacologic increase in serotonin concentrations on striatal dopamine (D2) receptor availability has been measured in several studies using positron emission tomography (PET) and the radiotracer [11C]-raclopride as a method for the in vivo imaging of serotonin modulation of striatal dopamine in human subjects. These studies have shown that an acute increase in serotonin concentrations produced a decrease in striatal D2 receptor availability. The current study was undertaken to measure the effects of a more pharmacologically selective serotonergic agent compared to previous studies, the serotonin reuptake inhibitor, citalopram, on striatal D2 receptor availability. Twelve healthy control subjects underwent two PET scans performed on the same day following i.v. administration of saline (Scan 1) and citalopram (Scan 2, 40 mg, i.v.). The [11C]-raclopride data were analyzed with a graphical analysis method using the cerebellum as the input function. Plasma levels of citalopram, cortisol, and prolactin were measured. The citalopram concentrations peaked at the end of infusion (EOI) and remained relatively consistent from 30 min to 3 h postinfusion. An increase in cortisol and prolactin concentrations was observed from the EOI until 60 min after the EOI. A significant decrease in striatal D2 receptor availability was observed after citalopram infusion (-5%), presumably due to an increase in endogenous dopamine concentrations. In summary, i.v. administration of the selective serotonin reuptake inhibitor, citalopram, produced modest reductions in striatal D2 receptor availability, consistent with other human [11C]-raclopride studies using less pharmacologically selective serotonergic agents.
File Format	HTM / HTML
ISSN	08874476
e-ISSN	10982396
DOI	10.1002/syn.20574
Journal	Synapse
Issue Number	1
Volume Number	63
Language	English
Publisher	Wiley
Publisher Date	2009-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Neurology Citalopram Pharmacology Corpus Striatum Dopamine Metabolism Positron-emission Tomography Raclopride Serotonin Uptake Inhibitors Carbon Radioisotopes Blood Drug Effects Receptors, Dopamine D2 Comparative Study Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience

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Selective Serotonin Reuptake Inhibitor (SSRI) Modulation of Striatal Dopamine Measured With [11C]-Raclopride and Positron Emission Tomography

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Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography.

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Selective Serotonin Reuptake Inhibitor (SSRI) Modulation of Striatal Dopamine Measured With [11C]-Raclopride and Positron Emission Tomography

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