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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nona, Christina N. Bermejo, Marie Kristel Ramsey, Amy J. Nobrega, José N. |
| Description | Country affiliation: Canada Author Affiliation: Nona CN ( Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.); Bermejo MK ( Behavioural Neurobiology Laboratory, Campbell Family Mental Health Research Institute, CAMH, Toronto, Ontario, Canada.); Ramsey AJ ( Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.); Nobrega JN ( Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.) |
| Abstract | Behavioral sensitization to various drugs of abuse has been shown to change dendritic spine density and/or morphology of nucleus accumbens (NAc) medium spiny neurons, an effect seen across drug classes. However, is it not known whether behavioral sensitization to ethanol (EtOH) is also associated with structural changes in this region. Here we compared dendritic spine density and morphology between mice showing High vs. Low levels of EtOH sensitization and found that high levels of EtOH sensitization were not associated with changes in dendritic spine density or spine type. Unexpectedly, however, a significant increase in the density of stubby-type spines was seen in mice that were resistant to sensitization. Since the presence of this spine type has been associated with long-term depression and cognitive/learning deficits this may explain why these mice fail to sensitize and why they show poor performance in conditioning tasks, as previously shown. A possible causal role for structural plasticity in behavioral sensitization to various drugs has been debated. In the case of EtOH sensitization, our results suggest that drug-induced changes in structural plasticity in the accumbens neurons may not be the cause of sensitized behavior. |
| File Format | HTM / HTML |
| ISSN | 08874476 |
| Issue Number | 12 |
| Volume Number | 69 |
| e-ISSN | 10982396 |
| Journal | Synapse |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Neurology Dendritic Spines Drug Effects Ethanol Pharmacology Nucleus Accumbens Physiology Animals Mice Cytology Synaptic Transmission Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cellular and Molecular Neuroscience |
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