NDLI: Toward exercise as personalized medicine.

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Toward exercise as personalized medicine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Buford, Thomas W. Roberts, Michael D. Church, Timothy S.
Description	Country affiliation: United States Author Affiliation: Buford TW ( Department of Aging and Geriatric Research, College of Medicine, University of Florida, PO Box 112610, Gainesville, FL 32611, USA. tbuford@ufl.edu)
Abstract	The early 21st century has witnessed a steady push by scientists, industry leaders, and government officials to make medicine more personalized. To date, the concept of personalized medicine has referred largely to the field of pharmacogenomics. In contrast, relatively few data exist regarding the application of preventive strategies such as physical exercise in the context of personalized medicine. Within this review, we highlight the extant literature and propose five strategies for scientists that may propel the exercise and sports science fields toward this global goal. Notably, these approaches are in addition to methods to maintain adherence to training - a well-known factor in determining exercise responsiveness. Briefly, these strategies include (1) evaluating participant responses to training at the individual as well as group level; (2) identifying sources of variability in responsiveness to training; (3) optimizing exercise dosing strategies to maximize benefits while minimizing barriers to participation; (4) evaluating the efficacy of multimodal interventions for relevant population subgroups; and (5) increasing the clinical relevance of study populations and outcomes in exercise trials. We look forward to seeing these strategies considered in trials of preventive health interventions such as exercise. Extensive future research in this area is needed for the vision of exercise as a personalized form of medicine to become a reality.
File Format	HTM / HTML
ISSN	01121642
e-ISSN	11792035
DOI	10.1007/s40279-013-0018-0
Journal	Sports Medicine
Issue Number	3
Volume Number	43
Language	English
Publisher	Springer
Publisher Date	2013-03-01
Publisher Place	New Zealand (Aotearoa)
Access Restriction	Open
Subject Keyword	Discipline Sports Medicine Exercise Therapy Individualized Medicine Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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