NDLI: Preparation and in vitro characterization of piroxicam enteric coated pellets using powder layering technique.

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Preparation and in vitro characterization of piroxicam enteric coated pellets using powder layering technique.

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Preparation and in vitro characterization of piroxicam enteric coated pellets using powder layering technique.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Varshosaz, Jaleh Tavakoli, Naser Serri, Azadeh
Description	Author Affiliation: Varshosaz J ( Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. varshosaz@pharm.mui.ac.ir)
Abstract	The objective of this study was to develop piroxicam enteric coated pellets using nonpareil seeds by powder layering technique to minimize its gastrointestinal adverse effects. Inert seeds were prepared by incorporating sugar, Avicel PH 101 and lactose. The obtained cores were then treated by PVP 10 w/v % solution using centrifugal granulator (CF-granulator) and then coated with micronized piroxicam using HPMC solution (8 w/v %) as binder. The piroxicam pellets were finally coated with different polymers (Eudragit L30D-55, Eudragit L100, Eudragit NE30D, Acryleze, or mixture of Eudragits L30D-55 and NE30D) and plasticizers (triethyl citrate and polyethylene glycol 6000). Results showed that Eudragit L30D-55 with 3% weight gain accompanied with TEC produced suitable enteric coated pellets.
File Format	HTM / HTML
ISSN	10837450
Issue Number	3
Volume Number	14
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents, Non-steroidal Administration & Dosage Drug Compounding Methods Piroxicam Tablets, Enteric-coated Chemistry Polymers Solubility Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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