NDLI: New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone).

Please wait, while we are loading the content...

Preparation and optimization of acetaminophen nanosuspension through nanoprecipitation using microfluidic devices: an artificial neural networks study.

Ultrastructural changes in bacterial membranes induced by nano-assemblies ß-cyclodextrin chlorhexidine: SEM, AFM, and TEM evaluation.

Drug silica nanocomposite: preparation, characterization and skin permeation studies.

Development of thermodynamically stable nanostructured lipid carrier system using central composite design for zero order permeation of econazole nitrate through epidermis.

Preparation and characterization of nimesulide containing nanocrystal formulations.

Nanoparticulate delivery of LHRH analogue for the treatment of prostate cancer.

Bicalutamide nanocrystals with improved oral bioavailability: in vitro and in vivo evaluation.

Effect of formulation compositions on niosomal preparations.

Nanoparticle formation by using shellac and chitosan for a protein delivery system.

A novel nanovesicular carrier system to deliver drug topically.

Effect of preparation conditions on the size and encapsulation properties of mPEG-PLGA nanoparticles simultaneously loaded with vincristine sulfate and curcumin.

Preparation and characterization of polymeric and lipid nanoparticles of pilocarpine HCl for ocular application.

Hydrocortisone-loaded poly(Îµ-caprolactone) nanoparticles for atopic dermatitis treatment.

Effect of fixed aqueous layer thickness of polymeric stabilizers on zeta potential and stability of aripiprazole nanosuspensions.

Identification of critical process parameters and its interplay with nanosuspension formulation prepared by top down media milling technology--a QbD perspective.

Brain targeted solid lipid nanoparticles for brain ischemia: preparation and in vitro characterization.

New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone).

Year: 2013 Volume: 18 Issue: 2

Year: 2013 Volume: 18 Issue: 1

Year: 2012 Volume: 17

Year: 2011 Volume: 16

Year: 2010 Volume: 15

Year: 2009 Volume: 14

Year: 2008 Volume: 13

New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ren, Fuzheng Gao, Yuan Chen, Jialei Jing, Qiufang Yu, Yan
Description	Country affiliation: China Author Affiliation: Ren F ( Department of Pharmaceutical Engineering, Shanghai Key Lab New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.)
Abstract	The objective of the study is to prepare a new self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymers methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone) (MPEG-b-PCL) and to investigate the effect of MPEG-b-PCL on the characteristics of SNEDDS. MPEG-b-PCL was synthesized and characterized by (1)H-NMR, IR and GPC. Various ratios of MPEG-b-PCL copolymers and Tween 80 were used as emulsifier to prepare the new SNEDDS. SNEDDS with high oil and low surfactant content forms a semi-solid gel at room temperature, which could be effectively sealed in soft or hard capsules. The mean droplet size of SNEDDS-generated nanoemulsions significantly decreased after the addition of diblock polymer and increased with increase of PCL chain in MPEG-b-PCL. The drug Coenzyme Q10 (CoQ10) was chosen as the model compound in this study due to its insolubility in water. CoQ10 from SNEDDS was rapidly dissolved regardless of the fluid condition.
File Format	HTM / HTML
ISSN	10837450
Issue Number	3
Volume Number	18
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Caproates Chemistry Drug Delivery Systems Methods Emulsifying Agents Chemical Synthesis Lactones Nanospheres Polyesters Polyethylene Glycols Administration & Dosage Polysorbates Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy

Rapamycin-loaded poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone) nanoparticles: preparation, characterization and potential application in corneal transplantation.

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

Folate-conjugated methoxy poly (ethylene glycol)/poly (L-Alanine) amphiphilic block copolymeric micelles for targeted delivery of paclitaxel

Acute toxicity and genotoxicity studies on poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone) nanomaterials.

Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(Ïµ-caprolactone)-poly(ethylene glycol) block copolymer based nanocarriers for protein delivery.

Biodegradable nanoparticles of methoxy poly(ethylene glycol)-b-poly( d, l-lactide)/methoxy poly(ethylene glycol)- b-poly(ϵ-caprolactone) blends for drug delivery

Novel Composite Drug Delivery System for Honokiol Delivery: Self-Assembled Poly(ethylene glycol)−Poly(ε-caprolactone)−Poly(ethylene glycol) Micelles in Thermosensitive Poly(ethylene glycol)−Poly(ε-caprolactone)−Poly(ethylene glycol) Hydrogel

Thermodynamic modeling for solubility prediction of indomethacin in self-nanoemulsifying drug delivery system (SNEDDS) and its individual components.

New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone).

Similar Documents

Etoposide-loaded biodegradable amphiphilic methoxy (poly ethylene glycol) and poly (epsilon caprolactone) copolymeric micelles as drug delivery vehicle for cancer therapy

Rapamycin-loaded poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone) nanoparticles: preparation, characterization and potential application in corneal transplantation.

Linear-dendrimer type methoxy-poly (ethylene glycol)-b-poly (ɛ-caprolactone) copolymer micelles for the delivery of curcumin

Folate-conjugated methoxy poly (ethylene glycol)/poly (L-Alanine) amphiphilic block copolymeric micelles for targeted delivery of paclitaxel

Acute toxicity and genotoxicity studies on poly(Îµ-caprolactone)-poly(ethylene glycol)-poly(Îµ-caprolactone) nanomaterials.

Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(Ïµ-caprolactone)-poly(ethylene glycol) block copolymer based nanocarriers for protein delivery.

Biodegradable nanoparticles of methoxy poly(ethylene glycol)-b-poly( d, l-lactide)/methoxy poly(ethylene glycol)- b-poly(ϵ-caprolactone) blends for drug delivery

Novel Composite Drug Delivery System for Honokiol Delivery: Self-Assembled Poly(ethylene glycol)−Poly(ε-caprolactone)−Poly(ethylene glycol) Micelles in Thermosensitive Poly(ethylene glycol)−Poly(ε-caprolactone)−Poly(ethylene glycol) Hydrogel

Thermodynamic modeling for solubility prediction of indomethacin in self-nanoemulsifying drug delivery system (SNEDDS) and its individual components.

New self-nanoemulsifying drug delivery system (SNEDDS) with amphiphilic diblock copolymer methoxy poly (ethylene glycol)-block-poly (Îµ-caprolactone).