NDLI: Formulation and evaluation of meloxicam niosomes as vesicular carriers for enhanced skin delivery.

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Formulation and evaluation of meloxicam niosomes as vesicular carriers for enhanced skin delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	El-Menshawe, Shahira F. Hussein, Amal K.
Description	Country affiliation: Egypt Author Affiliation: El-Menshawe SF ( Department of Pharmaceutics and Industrial Pharmacy, Beni Suef University, Beni Suef, Egypt. shahira.fawzy@gmail.com)
Abstract	CONTEXT: Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects. OBJECTIVES: The aim of this study was to develop transdermal MX in niosomes. MATERIALS AND METHODS: Vesicles prepared by thin film hydration method were characterized and the acute anti-inflammatory activity of 0.5% MX niosomal hydrogel was evaluated using carrageenan induced rat paw edema method. RESULTS: The results revealed that niosomes prepared from span 60 and cholesterol at 6:4 molar ratio using 20 mg of MX were of the highest entrapment efficiency (> 55%) and with particle size (187.3 nm). There was a marked increase in the percentage inhibition of edema in animals treated with MX vesicular gel compared to those treated with free MX and piroxicam gels. DISCUSSION: There was an inverse proportionality between vesicle size and cholesterol content. With increased cholesterol molar ratio the bilayer stability increased and permeability decreased leading to efficiently trapping the MX. In contrast, higher amounts of cholesterol may compete with the drug for packing space within the bilayer. The inhibitory effect of MX niosomal gel may be attributed to its superior skin permeation. CONCLUSIONS: The results suggest that niosomes may be promising vehicles for transdermal delivery of MX.
File Format	HTM / HTML
ISSN	10837450
Issue Number	4
Volume Number	18
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Anti-inflammatory Agents, Non-steroidal Administration & Dosage Drug Delivery Systems Skin Absorption Thiazines Thiazoles Administration, Cutaneous Animals Pharmacokinetics Pharmacology Carrageenan Toxicity Cholesterol Chemistry Disease Models, Animal Drug Carriers Edema Drug Therapy Pathology Gels Hexoses Inflammation Liposomes Male Particle Size Permeability Piroxicam Rats Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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