NDLI: Application of active layering and coating techniques in the development of a multiparticulate, controlled release dosage form of a high-dose, highly soluble drug.

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Application of active layering and coating techniques in the development of a multiparticulate, controlled release dosage form of a high-dose, highly soluble drug.

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Application of active layering and coating techniques in the development of a multiparticulate, controlled release dosage form of a high-dose, highly soluble drug.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ahmad, Haitham Khalifeh, Ismail Alkhalidi, Bashar Aiedeh, Khaled Alkhatib, Hatim S.
Description	Author Affiliation: Ahmad H ( Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan , Amman , Jordan and.)
Abstract	CONTEXT: The success of the development of controlled release, multilayered, multiparticulate dosage form of a high-dose, highly-soluble drug is dependent upon proper material and processing choices. OBJECTIVE: To develop a controlled release dosage form of diltiazem hydrochloride using active layering and coating. METHODS: Active layering was achieved by spraying a drug solution onto sugar cores using polyvinyl alcohol - polyethylene glycol as a binder. Layered pellets with highest loading and lowest binder content were coated using aqueous dispersions of polyvinyl acetate (PVAc). The effects of the plasticizer and curing on drug release were evaluated. RESULTS AND DISCUSSION: The binder level had no effect on the process efficiency. Drug release from PVAc-coated pellets was slowed by increasing PVAc level. Plasticization slowed drug release in comparison to nonplasticized formulations. Curing affected drug release of nonplasticized formulations only. Protection against humidity was essential in stabilizing drug release under stability study conditions. CONCLUSION: Materials and process used were suitable to face the challenge posed by the high dose of the water-soluble drug on the success of the formulation. The effects of the plasticizer, curing and ability of packaging to protect against elevated humidity on the performance of the studied system should be considered in development.
File Format	HTM / HTML
ISSN	10837450
Issue Number	5
Volume Number	19
e-ISSN	10979867
Journal	Pharmaceutical Development and Technology
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Pharmacology Antihypertensive Agents Administration & Dosage Delayed-action Preparations Chemistry Diltiazem Plasticizers Polyvinyls Drug Stability Humidity Solubility Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Pharmaceutical Science

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