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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hussen, Hozan Ismael Yang, Dong Cnattingius, Sven Moradi, Tahereh |
| Spatial Coverage | South America Europe Africa Latin America Sweden Asia |
| Description | Country affiliation: Sweden Author Affiliation: Hussen HI ( Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, SE-171 77, Stockholm, Sweden. Hozan.Hussen@ki.se) |
| Abstract | OBJECTIVE: To investigate associations between country of birth, parental country of birth, and education with respect to incidence rate and time trends of type 1 diabetes mellitus (T1DM) among children and young adults. METHODS: We followed a nation-wide cohort of 4 469 671 males and 4 231 680 females aged 0-30 years between 1969 and 2008. Incidence rate ratios (IRRs) with 95% confidence intervals (CIs) for T1DM were calculated using Poisson regression models. We further calculated age-standardized rates (ASRs) of T1DM, using the world population as standard. RESULTS: During the study period, the ASR of T1DM increased among children younger than 15 years, but not among young adults (15-30 years). Compared with Swedish-born children, male and female immigrant children had 44 and 42% lower IRR of TIDM, respectively. Among offspring to immigrants, corresponding decreases in IRRs were 27 and 24%, respectively. Compared with children to parents with high education, male children to parents with low education had a 10% decreased IRR of T1DM, while no effect was observed among females. The IRR of T1DM increased with increasing age and calendar time of follow-up in both sexes (p-for trend <0.0001). In young adults, the IRR among immigrants decreased by 32% in males and 22% in females, while corresponding reductions in IRRs were less in offspring to immigrants. CONCLUSIONS: We found a lower IRR of T1DM among offspring to immigrants, but especially among young immigrants compared with Sweden-born individuals. The findings show that environmental factors are important in the etiology of T1DM. |
| File Format | HTM / HTML |
| ISSN | 1399543X |
| Issue Number | 2 |
| Volume Number | 14 |
| e-ISSN | 13995448 |
| Journal | Pediatric Diabetes |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2013-03-01 |
| Publisher Place | Denmark |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Endocrinology Discipline Pediatrics Diabetes Mellitus, Type 1 Epidemiology Emigrants And Immigrants Socioeconomic Factors Adolescent Adult Africa Ethnology Asia Cohort Studies Educational Status Europe Female Humans Incidence Latin America Male Parents Sex Factors South America Sweden Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine Pediatrics, Perinatology and Child Health |
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