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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Monteiro, João P. Santos, Fátima M. Rocha, Ana S. Castro-de-Sousa, João P. Queiroz, João A. Passarinha, Luis A. Tomaz, Cândida T. |
| Description | Country affiliation: Portugal Author Affiliation: Monteiro JP ( CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.) |
| Abstract | The vitreous humor (VH) is the largest component of the eye. It is a colorless, gelatinous, highly hydrated matrix that fills the posterior segment of the eye between the lens and retina in vertebrates. In VH, a diversity of proteins that can influence retinal physiology is present, including growth factors, hormones, proteins with transporter activity, and enzymes. More importantly, the protein composition of VH has been described as being altered in a number of disease states. Therefore, attempts aiming at establishing a map of VH proteins and detecting putative biomarkers for ocular illness or protein fluctuations with putative physiologic significance were conducted over the last two decades, using proteomic approaches. Proteomic strategies often involve gel-based or LC techniques as sample fractioning approaches, subsequently coupled with MS procedures. This set of studies resulted in the proteomic characterization of a range of ocular disease samples, with particular incidence on diabetic retinopathy. However, practical therapeutic applications arising from these studies are scarce at the moment. A pertinent example of therapeutic targets arising from VH proteomics has emerged concerning vasoproliferative factors present in the vitreous, which should be involved in neovascularization and subsequent fibrovascular proliferation of the retina, in ocular disease context. Therefore, this review attempts to sum up the information acquired from the proteomic approaches to ocular disease conducted in VH samples, highlighting its clinical potential for disclosing ocular disease mechanisms and engendering pharmacological therapeutic treatments. |
| File Format | HTM / HTML |
| ISSN | 18628346 |
| Issue Number | 1-2 |
| Volume Number | 9 |
| e-ISSN | 18628354 |
| Journal | PROTEOMICS - Clinical Applications |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-02-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Biological Markers Metabolism Eye Diseases Diagnosis Eye Proteins Analysis Proteome Proteomics Methods Vitreous Body Pathology Animals Body Fluids Chemistry Humans Lens, Crystalline Neovascularization, Pathologic Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Clinical Biochemistry |
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