NDLI: Trends in patterns of anterior uveitis in a tertiary institution in singapore.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tan, Wai Jia Poh, Eugenie W. Wong, Poh-Ying Ho, Su-Ling Lim, Wee-Kiak Teoh, Stephen C.
Spatial Coverage	Singapore
Description	Country affiliation: Singapore Author Affiliation: Tan WJ ( National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.)
Abstract	PURPOSE: To report the trends in etiology of patients with anterior uveitis (AU) in Singapore over 6 years. METHODS: A retrospective review of the clinical records of all new patients who presented with anterior uveitis to the uveitis subspecialty clinic from 2005 to 2010 at Tan Tock Seng Hospital, Singapore. RESULTS: There were 552 new cases of AU. This comprised 59.5% of a total of 928 new patients diagnosed with uveitis from 2005 to 2010. The mean age was 48.0 ± 17.2 years. There was a male predominance (62.5%), with a male:female ratio of 1.7:1. The majority were of Chinese ethnicity (69%), followed by Malays (13.2%). Most cases were unilateral (79.5%) and idiopathic (50.4%). Common etiological causes included Fuchs heterochromic iridocyclitis (FHI) (5.6%), ankylosing spondylitis (AS)-related AU (5.1%), herpes simplex virus (HSV) (4.7%), and herpes zoster virus (HZV) (4.5%). There were increasing trends in AS-related AU from 3.2% in 2008 to 6.5% in 2010, and psoriasis-associated AU from 1.7% in 2005 to 4.0% in 2008. There were decreasing trends in the incidence of FHI from 10.6% in 2006 to 4.7% in 2009. No change in incidence of viral etiologies was noted, but cytomegalovirus-related immune-recovery uveitis (IRU) comprised 7.4%. IRU showed an increasing trend from 1.7% in 2005 to 11.9% in 2007, then decreased to 3.3% in 2010. Using the Pearson chi-square test, there was no statistically significant association between ethnicities (Chinese, Malay, Indian) comparing infectious and noninfectious cases (p = 0.788), idiopathic and nonidiopathic cases (p = 0.170), or between the various etiologies of uveitis (p = 0.168). CONCLUSIONS: AU was the predominant form of uveitis seen at our centers. Infectious etiologies (18.5%) are the most common among nonidiopathic cases, with herpes viruses (9.2%) being most prevalent. Despite increased use of polymerase chain reaction (PCR) in the detection of microbial and viral DNA, there was no overall increase in detection of infectious causes for uveitis. The changes in CMV-related immune recovery uveitis from 2005 to 2010 could reflect a change in HIV management in Singapore.
File Format	HTM / HTML
ISSN	09273948
e-ISSN	17445078
Journal	Ocular Immunology and Inflammation
Issue Number	4
Volume Number	21
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-08-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Ophthalmology Discipline Immunology Tertiary Care Centers Statistics & Numerical Data Uveitis, Anterior Epidemiology Adolescent Retrospective Studies Singapore Diagnosis Comparative Study
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Immunology and Allergy

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