NDLI: Possible interaction between letrozole and long-acting injectable zuclopenthixol.

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Possible interaction between letrozole and long-acting injectable zuclopenthixol.

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Possible interaction between letrozole and long-acting injectable zuclopenthixol.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lertxundi, Unax Hernandez, Rafael Albeniz, Juan Medrano Echaburu, Saioa Domingo Ruiz, Borja García, Montserrat García Aguirre, Carmelo
Description	Country affiliation: Spain Author Affiliation: Lertxundi U ( Unax Lertxundi, Pharm.D., Pharmacy Service, Red de Salud Mental de Araba , C/Alava 43, 01006 Vitoria-Gasteiz, Alava , Spain .)
Abstract	Mrs A, a 68-year-old woman with paranoid schizophrenia, was on long-term psychiatric treatment with long-acting intramuscular zuclopenthixol, quetiapine and alprazolam when, in April 2012, she was diagnosed with right breast infiltrating ductal carcinoma. After starting treatment with letrozole on 4 July, Mrs A progressively developed extrapyramidal symptoms and these were particularly evident after each zuclopenthixol administration. On 9 January, both quetiapine and alprazolam were stopped due to excessive lethargy. After the administration of the last dose of zuclopenthixol on 26 January, she presented with sedation, sialorrhea, festinant gait, axial dystonia and dysphagia, all of which were severe. The introduction of letrozole was the only change that had been made to her pharmacotherapeutic regimen in that period. The rest of the findings on neurological examination were normal. Renal function was adequate. Slow symptom onset and progressive worsening until full-blown clinical presentation after 6 months, and the dramatic improvement in the clinical picture achieved 2 days after treatment with biperiden, suggests a long-term insidious interaction leading to zuclopenthixol accumulation. To the best of our knowledge, this is the first report of a possible interaction between letrozole and zuclopenthixol. We consider that it warrants further investigation. In the meanwhile, physicians should be aware of the occurrence of this potentially serious drug-drug interaction.
File Format	HTM / HTML
ISSN	08039488
Issue Number	1
Volume Number	69
e-ISSN	15024725
Journal	Nordic Journal of Psychiatry
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-01-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Psychiatry Antineoplastic Agents Adverse Effects Antipsychotic Agents Clopenthixol Nitriles Schizophrenia Drug Therapy Triazoles Aged Basal Ganglia Diseases Chemically Induced Dibenzothiazepines Drug Interactions Female Humans Quetiapine Fumarate Case Reports Letter
Content Type	Text
Resource Type	Case study Article
Subject	Psychiatry and Mental Health

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