NDLI: Increased ratio of vascular endothelial growth factor to semaphorin3A is a negative prognostic factor in human meningiomas.

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Increased ratio of vascular endothelial growth factor to semaphorin3A is a negative prognostic factor in human meningiomas.

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Increased ratio of vascular endothelial growth factor to semaphorin3A is a negative prognostic factor in human meningiomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Barresi, Valeria Tuccari, Giovanni
Description	Country affiliation: Italy Author Affiliation: Barresi V ( Department of Human Pathology, University of Messina, Messina, Italy.); Tuccari G ( Department of Human Pathology, University of Messina, Messina, Italy.)
Abstract	Semaphorin3A (SEMA3A) is an anti-angiogenic factor which is expressed in human meningiomas in association with low microvessel density (MVD). It competes with vascular endothelial growth factor (VEGF) for receptor neuropilin-1 (NRP-1). The ratio between VEGF and SEMA3A has been recently demonstrated to regulate neo-angiogenesis, proliferation and progression of tumors. To clarify the involvement of these proteins in the above-mentioned phenomena, we analyzed the immunohistochemical expression of SEMA3A, VEGF and NRP-1 and their correlation with MVD in a series of 48 cases of meningioma with different histotype and histological grade. SEMA3A and VEGF expression was encountered in about half the cases, although at different levels. NRP-1 staining was evidenced in the vessels within all but two tumors and in the neoplastic cells of 18/48 meningiomas. A negative significant correlation emerged between SEMA3A amount and MVD; on the other hand, high VEGF levels appeared to be significantly associated with high MVD. A high VEGF/SEMA3A was significantly associated with high histological grade, proliferation index and MVD as well as with a higher recurrence rate of the meningiomas. Present data suggest that the balance between the expression of the pro-angiogenic factor VEGF and the anti-angiogenic SEMA3A may be involved in the regulation of neo-angiogenesis and proliferation in meningiomas, representing also a predictor of recurrences in these tumors. Further validation of our results may open the way for the use of drugs targeting not only VEGF, but also NRP-1 and SEMA3A to prevent recurrences of meningiomas.
File Format	HTM / HTML
ISSN	09196544
Issue Number	5
Volume Number	30
e-ISSN	14401789
Journal	Neuropathology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-10-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neurology Discipline Pathology Meningeal Neoplasms Diagnosis Metabolism Meningioma Neuropilin-1 Semaphorin-3a Vascular Endothelial Growth Factor A Adult Aged Aged, 80 And Over Female Humans Kaplan-meier Estimate Male Mortality Pathology Microvessels Middle Aged Neovascularization, Pathologic Prognosis Journal Article
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Pathology and Forensic Medicine

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