NDLI: Increased waist circumference is the component of metabolic syndrome the most strongly associated with elevated C-reactive protein in elderly.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Assoumou, Hourfil-Gabin Ntougou Barthelemy, Jean Claude Garet, Martin Dauphinot, Virginie Celle, Sébastien Pichot, Vincent Kossovsky, Michel Gaspoz, Jean-Michel Roche, Frédéric
Description	Country affiliation: France Author Affiliation: Assoumou HG ( Clinical and Exercise Physiology Laboratory, University Hospital and Jean Monnet University, PRES University of Lyon, Saint-Etienne, France.)
Abstract	BACKGROUND: Metabolic syndrome is associated with higher C-reactive protein (CRP) serum levels, a common biological marker of inflammation. However, the respective contribution of each component of metabolic syndrome to the inflammation has not been established. The aim of the present study was to assess the strength of the association between metabolic syndrome components and CRP in elderly subjects. METHODS: This was an observational, cross-sectional study on 921 volunteers (65.6 ± 0.8 years old) from the PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events) Study. Anthropometric, biological, and clinical parameters were evaluated. Subjects with a CRP value less than 10 mg/L were considered. The relationships between the metabolic syndrome components and CRP tertiles were evaluated using logistic regression analysis. RESULTS: After adjustment for gender and for body mass index, metabolic syndrome and high-CRP tertile were significantly associated [odds ratio (OR)=2.37, 95% confidence interval (CI) 1.46-3.87, P<0.001]. Waist circumference demonstrated the strongest association with the high-CRP tertile (OR=1.75, 95% CI 1.05-2.91, P<0.05). In addition, CRP levels significantly increased with the number of metabolic syndrome components. CONCLUSIONS: Among metabolic syndrome components, waist circumference showed the strongest association with the high-CRP tertile in elderly subjects. These findings help to explain the strong association between waist circumference and cardiovascular morbidity.
File Format	HTM / HTML
ISSN	15404196
Issue Number	4
Volume Number	9
e-ISSN	15578518
Journal	Metabolic Syndrome and Related Disorders
Language	English
Publisher	Mary Ann Liebert
Publisher Date	2011-08-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Metabolism C-reactive Protein Metabolism Metabolic Syndrome X Blood Pathology Waist Circumference Aged Biological Markers Cardiovascular Diseases Etiology Cross-sectional Studies Female Humans Male Complications Odds Ratio Prognosis Risk Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine

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