NDLI: An Inner Ear Gene Expression Database

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An Inner Ear Gene Expression Database

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An Inner Ear Gene Expression Database

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Zheng-Yi Corey, David P.
Description	Country affiliation: United States Author Affiliation: Chen ZY ( Neurology Service, Massachusetts General Hospital, Boston 02114, USA. zhengyi@helix.mgh.harvard.edu)
Abstract	Microarray technology has provided an unprecedented opportunity to study gene expression profiles at a whole-genome level. As a first step toward a comprehensive understanding of inner ear gene expression, mouse cochleas were examined at two developmental stages (P2 and P32) using GeneChip oligonucleotide arrays. A large number of genes and ESTs (>10,000) were found to be expressed in the cochlea. Expression profiles derived from duplicate samples at the same developmental stages showed general agreement and indicated the reproducibility of the assay. The expression of many known hair-cell genes was detected in the whole-cochlea samples, demonstrating the relatively high sensitivity of the assay. Genes highly expressed only at P2 or P32 were also identified and their expression patterns correlate with their functions in the cochlea. A web-based database with external links was set up for public access, which should facilitate the discovery of genes important in the development and function of the inner ear and should aid the identification of additional deafness genes.
File Format	HTM / HTML
ISSN	15253961
e-ISSN	14387573
Journal	Journal of the Association for Research in Otolaryngology
Issue Number	2
Volume Number	3
Language	English
Publisher	Springer
Publisher Date	2002-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Otolaryngology Cochlea Physiology Databases, Factual Gene Expression Profiling Animals Deafness Genetics Gene Expression Regulation, Developmental Genomics Mice Multigene Family Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Differential expression of genes within the cochlea as defined by a custom mouse inner ear microarray.

Gene discovery in the auditory system: characterization of additional cochlear-expressed sequences.

Conditional gene expression in the mouse inner ear using Cre-loxP.

Development of the gerbil inner ear observed in the hemicochlea.

Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness.

A comprehensive network and pathway analysis of human deafness genes.

A Sox10(rtTA/+) Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear.

Expression of the Olig gene family in the developing mouse inner ear.

Topological and developmental gradients of calbindin expression in the chick's inner ear.

An Inner Ear Gene Expression Database

Similar Documents

Differential expression of genes within the cochlea as defined by a custom mouse inner ear microarray.

Gene discovery in the auditory system: characterization of additional cochlear-expressed sequences.

Conditional gene expression in the mouse inner ear using Cre-loxP.

Development of the gerbil inner ear observed in the hemicochlea.

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A comprehensive network and pathway analysis of human deafness genes.

A Sox10(rtTA/+) Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear.

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An Inner Ear Gene Expression Database