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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Le Prell, Colleen G. Halsey, Kärin Hughes, Larry F. Dolan, David F. Bledsoe, Sanford C. |
| Description | Country affiliation: United States Author Affiliation: Le Prell CG ( Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, USA. colleeng@umich.edu) |
| Abstract | We applied the dopaminergic (DA) neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to the guinea pig cochlear perilymph. Immunolabeling of lateral olivocochlear (LOC) neurons using antibodies against synaptophysin was reduced after the MPTP treatment. In contrast, labeling of the medial olivocochlear innervation remained intact. As after brainstem lesions of the lateral superior olive (LSO), the site of origin of the LOC neurons, the main effect of disrupting LOC innervation of the cochlea via MPTP was a depression of the amplitude of the compound action potential (CAP). CAP amplitude depression was similar to that produced by LSO lesions. Latency of the N1 component of the CAP, and distortion product otoacoustic emission amplitude and adaptation were unchanged by the MPTP treatment. This technique for selectively lesioning descending LOC efferents provides a new opportunity for examining LOC modulation of afferent activity and behavioral measures of perception. |
| File Format | HTM / HTML |
| ISSN | 15253961 |
| e-ISSN | 14387573 |
| Journal | Journal of the Association for Research in Otolaryngology |
| Issue Number | 1 |
| Volume Number | 6 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2005-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Otolaryngology Cochlear Nerve Physiology Cochlear Nucleus Dopamine Evoked Potentials, Auditory, Brain Stem Olivary Nucleus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Pharmacology Action Potentials Adaptation, Physiological Drug Effects Animals Pathology Denervation Dopamine Agents Guinea Pigs Immunohistochemistry Neurotoxins Otoacoustic Emissions, Spontaneous Research Support, N.i.h., Extramural Research Support, U.s. Gov't, P.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Sensory Systems |
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