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Toxicokinetics and absolute oral bioavailability of melamine in broiler chickens.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Poapolathep, S. Klangkaew, N. Arreesrisom, P. Isariyodom, S. Sugita-Konishi, Y. Kumagai, S. Poapolathep, A.
Description	Country affiliation: Thailand Author Affiliation: Poapolathep S ( Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand.)
Abstract	The objective of this study was to investigate the toxicokinetic characteristics of melamine in broilers due to the limited information available for livestock. Melamine was then administered to broiler chickens at an intravenous (i.v.) or oral (p.o.) dosage of 5.5 mg/kg of body weight, and plasma samples were collected up to 48 h. The concentration of melamine in each plasma sample was analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Melamine was measurable up to 24 h after i.v. and p.o. administration. A one-compartment model was developed to describe the toxicokinetics of melamine in broilers. Following i.v. administration, the values for the elimination half-life (t(1/2ß)), the volume of distribution (Vd ), and the clearance (CL) were 4.42 ± 1.02 h, 00.52 ± 0.18 L/kg, and 0.08 ± 0.01 L/h/kg, respectively. The absolute oral bioavailability (F) was 95.63 ± 3.54%. The results suggest that most of the administered melamine is favorably absorbed from the alimentary tract and rapidly cleared by the kidneys in broiler chickens.
File Format	HTM / HTML
ISSN	01407783
Issue Number	1
Volume Number	38
e-ISSN	13652885
Journal	Journal of Veterinary Pharmacology and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-02-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Discipline Veterinary Medicine Discipline Pharmacology Chickens Blood Triazines Pharmacokinetics Administration, Oral Animals Area Under Curve Biological Availability Half-life Administration & Dosage Toxicity Clinical Trial Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Veterinary Pharmacology

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