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Year: 2010 Volume: 56 Issue: 1

Year: 2009 Volume: 55

Clinical profile of primary hyperparathyroidism from western India: a single center experience.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gopal, R. A. Acharya, S. V. Bandgar, T. Menon, P. S. Dalvi, A. N. Shah, N. S.
Spatial Coverage	India
Description	Country affiliation: India Author Affiliation: Gopal RA ( Department of Endocrinology, KEM Hospital, Parel, Mumbai, India.)
Abstract	BACKGROUND: Primary hyperparathyroidism (PHPT) has a variable clinical presentation and symptomatic PHPT is still the predominant form of the disease in India. Data from western India is lacking. AIM: To present the clinical profile of PHPT from western India. SETTINGS AND DESIGN: This retrospective study was conducted at a tertiary care referral center. MATERIALS AND METHODS: We analyzed the clinical presentation, biochemical, radiological features, and operative findings in adult patients with PHPT (1986-2008) and compared with our published data of children and adolescent patients with PHPT. STATISTICAL ANALYSIS: was done with SPSS 16 software. RESULTS: Seventy-nine patients (F: M-2:1) with age ranging from 21 to 55 years (mean 33.5+/-8.82) were analyzed. Skeletal manifestations (75.5%), renal calculi (40.5%) and proximal muscle weakness (45.5%) were the most common symptoms of presentation with mean duration of symptoms being 33.70 (median: 24, range 1-120) months. Biochemical features included hypercalcemia (total corrected calcium 12.55+/-1.77 mg/dl), low inorganic phosphorus (1.81+/-0.682 mg/dl), elevated total alkaline phosphatase (mean: 762.2; median: 559; range: 50-4930IU/L) and high parathyroid hormone (PTH) (mean+/-SD: 866.61+/-799.15; median: 639.5; range: 52-3820 pg/ml). Preoperative localization was achieved in 74 patients and single adenoma was found during surgery in 72 patients. Hungry bone disease was seen in 30.3% and transient hypoparathyroidism developed in 62% patients. In comparison to PHPT in children there were no significant differences with regard to clinical, laboratory and radiological features. CONCLUSIONS: PHPT in western India is symptomatic disorder with skeletal and renal manifestations at a much younger age. Clinical profile of PHPT in children is similar to that of adults.
File Format	HTM / HTML
ISSN	00223859
e-ISSN	09722823
Journal	Journal of Postgraduate Medicine
Issue Number	2
Volume Number	56
Language	English
Publisher	MedKnow Publication
Publisher Date	2010-04-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Discipline Medicine Bone Diseases Complications Calcium Blood Hyperparathyroidism, Primary Vitamin D Deficiency Alkaline Phosphatase Etiology Surgery Parathyroid Glands Pathology Parathyroid Hormone Parathyroidectomy Radionuclide Imaging Retrospective Studies Ultrasonography
Content Type	Text
Resource Type	Article
Subject	Medicine

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