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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Woo, Seon Min Min, Kyoung-jin Kwon, Taeg Kyu |
| Description | Country affiliation: South Korea Author Affiliation: Woo SM ( Department of Immunology, School of Medicine, Keimyung University, Dalseo-Gu, Daegu, South Korea.) |
| Abstract | Melatonin is involved in many physiological functions, and it has differential effects on apoptosis in normal and cancer cells. However, the mechanism of its antitumor roles is not well understood. In this study, we show that melatonin enhances tunicamycin-induced apoptosis in human breast carcinoma MDA-MB-231 cells. Melatonin up-regulates pro-apoptotic protein Bim expression at the transcriptional levels in the presence of tunicamycin. Melatonin inhibits tunicamycin-induced COX-2 expression in MDA-MB-231 cells. Furthermore, inhibition of COX-2 activity using the COX-2 inhibitor, NS398, increases tunicamycin-induced apoptosis. Interestingly, these effects were not associated with melatonin receptor signal pathways. Pertussis toxin (a general Gi protein inhibitor) or luzindole (a nonspecific melatonin receptor antagonist) did not reverse the effect of melatonin. In addition, melatonin blocked tunicamycin-induced NF-κB transcriptional activity, p65 nuclear translocation, and p38 MAPK activation. Melatonin-mediated p38 MAPK inhibition contributed to decreased COX-2 mRNA stability. Taken together, our results suggest that melatonin enhances antitumor function through up-regulation of Bim expression and down-regulation of COX-2 expression in tunicamycin-treated MDA-MB-231 cells. |
| File Format | HTM / HTML |
| ISSN | 07423098 |
| Issue Number | 3 |
| Volume Number | 58 |
| e-ISSN | 1600079X |
| Journal | Journal of Pineal Research |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Endocrinology Apoptosis Regulatory Proteins Metabolism Apoptosis Drug Effects Cyclooxygenase 2 Gene Expression Regulation, Neoplastic Melatonin Pharmacology Membrane Proteins Proto-oncogene Proteins Tunicamycin Genetics Cell Line, Tumor Down-regulation Humans Nf-kappa B Up-regulation Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology |
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