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Efficacy of preoperative dexamethasone for postoperative nausea and vomiting after laparoscopic cholecystectomy: a large-scale, multicenter, randomized, double-blind, placebo-controlled trial in Japan.

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Efficacy of preoperative dexamethasone for postoperative nausea and vomiting after laparoscopic cholecystectomy: a large-scale, multicenter, randomized, double-blind, placebo-controlled trial in Japan.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wakasugi, Masaki Tori, Masayuki Shimizu, Junzo Kim, Yong Kook Noda, Takehiro Dono, Keizo Takeda, Yutaka Yamamoto, Tameyoshi Oshima, Satoshi Morimoto, Yoshikazu Asaoka, Tadafumi Eguchi, Hidetoshi Nagano, Hiroaki Mori, Masaki Doki, Yuichiro
Spatial Coverage	Japan
Description	Country affiliation: Japan Author Affiliation: Wakasugi M ( Department of Surgery, Osaka Police Hospital, Osaka, Japan.); Tori M ( Department of Surgery, Osaka Police Hospital, Osaka, Japan.); Shimizu J ( Department of Surgery, Osaka Rosai Hospital, Sakai, Japan.); Kim YK ( Department of Surgery, Kaizuka City Hospital, Kaizuka, Japan.); Noda T ( Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan.); Dono K ( Department of Surgery, Toyonaka Municipal Hospital, Toyonaka, Japan.); Takeda Y ( Department of Surgery, Kansai Rosai Hospital, Amagasaki, Japan.); Yamamoto T ( Department of Surgery, Sakai Municipal Hospital, Sakai, Japan.); Oshima S ( Department of Surgery, Minoh City Hospital, Minoh, Japan.); Morimoto Y ( Department of Surgery, Osaka Hospital, Osaka, Japan.); Asaoka T ( Department of Surgery, Osaka National Hospital, Osaka, Japan.); Eguchi H ( Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.); Nagano H ( Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.); Mori M ( Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.); Doki Y ( Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.)
Abstract	BACKGROUND: To assess the efficacy of preoperative dexamethasone for postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy (LC) in Japan. METHODS: A total of 270 patients at eight hospitals were randomized to receive dexamethasone 8 mg (n = 136) or placebo (n = 134) intravenously before LC. The primary endpoint was the degree of PONV and antiemetic requirements within 24 h after LC. Secondary endpoints were postoperative complications, postoperative hospital stay, and cost of hospital stay. This study was registered: UMIN-CTR (UMIN000003841). RESULTS: Within 6 h after LC, 17% (23/136) of patients in the dexamethasone group versus 24% (32/134) in the placebo group reported nausea (P = 0.3), and 5% (7/136) versus 7% (10/134) reported vomiting (P = 0.2). Metoclopramide 10 mg was used 0.09 ± 0.31 versus 0.14 ± 0.35 times (P = 0.2). From 6 to 24 h, 10% (14/136) versus 13% (17/134) reported nausea (P = 0.5), and 5% (7/136) versus 5% (7/134) reported vomiting (P = 0.8). Metoclopramide was used 0.04 ± 0.19 versus 0.03 ± 0.17 times (P = 0.8). Postoperative complications and postoperative hospital stay did not differ significantly between the two groups, but the cost of hospital stay was slightly higher in the dexamethasone group (P < 0.05). CONCLUSIONS: Routine use of preoperative dexamethasone for PONV after elective LC in Japan was not shown to have a clinical advantage.
File Format	HTM / HTML
ISSN	18686974
Issue Number	11
Volume Number	22
e-ISSN	18686982
Journal	Journal of Hepato-Biliary-Pancreatic Sciences
Language	English
Publisher	Wiley
Publisher Date	2015-11-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Gastroenterology Antiemetics Administration & Dosage Cholecystectomy, Laparoscopic Adverse Effects Dexamethasone Postoperative Nausea And Vomiting Prevention & Control Adult Aged Methods Double-blind Method Female Follow-up Studies Humans Infusions, Intravenous Japan Length Of Stay Male Middle Aged Etiology Preoperative Care Reference Values Statistics, Nonparametric Treatment Outcome Young Adult Journal Article Multicenter Study Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Hepatology Surgery

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