NDLI: A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients.

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A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoshioka, Toru Okimoto, Nobukazu Okamoto, Ken Sakai, Akinori
Description	Country affiliation: Japan Author Affiliation: Yoshioka T ( Department of Orthopaedics, Sakamidorii Hospital, 6-28-1 Midorii, Asaminami-ku, Hiroshima, Hiroshima, 731-0103, Japan. t-yossy@rc4.so-net.ne.jp)
Abstract	The purpose of the present study was to precisely compare both the efficacy and abdominal symptom-related quality of life after treatment with daily minodronate and weekly alendronate in patients with primary postmenopausal osteoporosis. The efficacy of the two drugs was assessed based on improvements in a bone turnover marker, back pain, and gastrointestinal symptoms that impair quality of life, which was assessed using the Izumo scale questionnaire. In the minodronate group, there were no significant changes during the treatment period in the specific scores for heartburn, epigastralgia and epigastric fullness, whereas all of the scores were significantly elevated at some time point after drug administration in the alendronate group. Urinary N-telopeptide of type I collagen (uNTX), a bone resorption marker, and bone-specific alkaline phosphatase, a bone formation marker, significantly decreased in both groups, but decreases in uNTX in the minodronate group was observed significantly earlier compared with those in the alendronate group. The back pain scores, which were obtained using a visual analog scale, were significantly reduced in both groups. However, analgesic effects were detected earlier in the minodronate group. In conclusion, compared with weekly alendronate, daily minodronate improved bone turnover and back pain more promptly without causing upper gastrointestinal symptoms.
File Format	HTM / HTML
ISSN	09148779
Issue Number	2
Volume Number	31
e-ISSN	14355604
Journal	Journal of Bone and Mineral Metabolism
Language	English
Publisher	Springer
Publisher Date	2013-03-01
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Alendronate Adverse Effects Therapeutic Use Back Pain Drug Therapy Bone Resorption Diphosphonates Gastrointestinal Tract Drug Effects Imidazoles Osteoporosis, Postmenopausal Aged Administration & Dosage Complications Physiopathology Urine Biological Markers Metabolism Bone Density Bone Density Conservation Agents Bone Remodeling Collagen Type I Drug Administration Schedule Female Pathology Humans Pain Measurement Peptides Questionnaires Comparative Study Journal Article Multicenter Study Randomized Controlled Trial
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Endocrinology, Diabetes and Metabolism Endocrinology

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