NDLI: Admixture analysis in relation to pedigree studies of introgression in a minority British cattle breed: the Lincoln Red.

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Admixture analysis in relation to pedigree studies of introgression in a minority British cattle breed: the Lincoln Red.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bray, T. C. Hall, S. J. G. Bruford, M. W.
Description	Country affiliation: United kingdom Author Affiliation: Bray TC ( Cardiff School of Biosciences, Cardiff University, Cardiff, UK)
Abstract	Investigation of historic population processes using molecular data has been facilitated by the use of approximate Bayesian computation (ABC), which enables the consideration of multiple alternative demographic scenarios. The Lincoln Red cattle breed provides a relatively simple example of two well-documented admixture events. Using molecular data for this breed, we found that structure did not resolve very low (<5% levels) of introgression, possibly due to sampling limitations. We evaluated the performance of two ABC approaches (2BAD and DIYABC) against those of two earlier methodologies, ADMIX and LEADMIX, by comparing their interpretations with the conclusions drawn from herdbook analysis. The ABC methods gave credible values for the proportions of the Lincoln Red genotype that are attributable to Aberdeen Angus and Limousin, although estimates of effective population size and event timing were not realistic. We suggest ABC methods are a valuable supplement to pedigree-based studies but that the accuracy of admixture determination is likely to diminish with increasing complexity of the admixture scenario.
File Format	HTM / HTML
ISSN	09312668
Issue Number	1
Volume Number	131
e-ISSN	14390388
Journal	Journal of Animal Breeding and Genetics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2014-02-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Genetics Discipline Reproductive Medicine Discipline Veterinary Medicine Discipline Zoology Breeding Genetics, Population Genotype Algorithms Animals Bayes Theorem Cattle Pedigree Polymorphism, Single Nucleotide Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Animal Science and Zoology Food Animals

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