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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nakasato, Tatsuhiko Izumisawa, Mitsuru Akahane, Akio Kikuchi, Koyo Ehara, Shigeru Shoji, Satoru Kogi, Shintaro Mizuki, Harumi Sugiyama, Yoshiki |
| Description | Country affiliation: Japan Author Affiliation: Nakasato T ( Department of Radiology, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. nakasato@iwate-med.ac.jp) |
| Abstract | PURPOSE: The purpose of this study was to show the effectiveness of combining intra-arterial infusion and systemic chemotherapy with concurrent radiotherapy for treatment of stage IV mandibular gingival cancer. MATERIALS AND METHODS: A total of 23 patients with mandibular gingival cancer were treated with either docetaxel by intra-arterial infusion followed by systemic chemoradiotherapy with cisplatinum and 5-fluorouracil as a monthly regimen, or with docetaxel and cisplatinum by intra-arterial infusion followed by systemic chemoradiotherapy with 5-fluorouracil as a weekly or biweekly regimen. Tumor responses, locoregional control, overall survival, disease-specific survival, and adverse events were evaluated. RESULTS: Of the 23 patients enrolled in the study, 22 completed the treatment. With regard to clinical stages, 82 % were diagnosed as IVA and 18 % IVB. Complete and partial response was observed in 82 and 18 %, respectively. Five-year overall survival, disease-specific survival, and locoregional control were 51, 70, and 72 %, respectively. No statistically significant difference was seen between the monthly regimen and the weekly plus biweekly regimen, although the latter resulted in longer survival and 88 % control. CONCLUSION: Combined intra-arterial infusion and systemic chemoradiotherapy may be an effective treatment for patients with stage IV mandibular gingival cancer. |
| File Format | HTM / HTML |
| ISSN | 18671071 |
| Issue Number | 9 |
| Volume Number | 30 |
| e-ISSN | 1867108X |
| Journal | Japanese Journal of Radiology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-11-01 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Diagnostic Imaging Discipline Radiology Carcinoma, Squamous Cell Therapy Chemoradiotherapy Gingival Neoplasms Aged Aged, 80 And Over Antineoplastic Agents Administration & Dosage Cisplatin Combined Modality Therapy Drug Administration Schedule Female Fluorouracil Humans Infusions, Intra-arterial Male Mandible Middle Aged Taxoids Treatment Outcome Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging |
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