NDLI: Do statins reduce the cardiovascular risk in patients with rheumatoid arthritis?

Please wait, while we are loading the content...

Year: 2016 Volume: 19

Year: 2015 Volume: 18

Year: 2014 Volume: 17

Year: 2014 Volume: 17 Issue: 8

Year: 2014 Volume: 17 Issue: 7

Year: 2014 Volume: 17 Issue: 6

Greater trochanteric pain syndrome: does imaging-identified pathology influence the outcome of interventions?

Assessment of the relationship between aortic stiffness and left ventricular functions with echocardiography in patients with Sjögren's syndrome.

Diagnostic dilemma of paraneoplastic arthritis: case series.

A case series of autoimmune diseases accompanied by incidentally diagnosed monoclonal gammopathy: is there a link between the two diseases?

An allopurinol-controlled, multicenter, randomized, double-blind, parallel between-group, comparative study of febuxostat in Chinese patients with gout and hyperuricemia.

Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis.

The diagnostic value of ultrasound compared with nerve conduction velocity in carpal tunnel syndrome.

Comparing female-based contraceptive methods in patients with systemic lupus erythematosus, rheumatoid arthritis and a healthy population.

Hairy cell leukemia presenting initially with symptoms of Behçet's disease.

Population attributable risk from obesity to arthritis in the Canadian Population Health Longitudinal Survey 1994-2006.

Potential biomarkers and latent pathways for vasculitis based on latent pathway identification analysis.

Do statins reduce the cardiovascular risk in patients with rheumatoid arthritis?

Year: 2014 Volume: 17 Issue: 5

Year: 2014 Volume: 17 Issue: 4

Year: 2014 Volume: 17 Issue: 3

Year: 2014 Volume: 17 Issue: Supplementary 3

Year: 2014 Volume: 17 Issue: 2

Year: 2014 Volume: 17 Issue: 1

Year: 2013 Volume: 16

Year: 2012 Volume: 15

Year: 2011 Volume: 14

Year: 2010 Volume: 13

Year: 2009 Volume: 12

Do statins reduce the cardiovascular risk in patients with rheumatoid arthritis?

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Danninger, Kathrin Hoppe, Uta C. Pieringer, Herwig
Description	Country affiliation: Austria Author Affiliation: Danninger K ( Academic Research Unit, 2nd Department of Medicine, General Hospital Linz, Linz, Austria.)
Abstract	OBJECTIVE: Patients with rheumatoid arthritis (RA) are at significantly higher risk of cardiovascular (CV) morbidity and mortality compared with the general population. Traditional CV risk factors cannot explain the total excess of CV morbidity and mortality in RA patients. At present, it is not clear whether treatment with statins might be of benefit in RA patients. The aim of the present systematic literature review is to summarize the published evidence concerning treatment with statins and its impact on CV events in RA patients. METHODS: A systematic literature review of studies on RA and statins was carried out in the database PubMed. Search terms were 'simvastatin OR atorvastatin OR fluvastatin OR lovastatin OR pravastatin OR rosuvastatin OR statin AND arthritis'. Papers were included in this review when the reported outcome was on CV events in RA patients. After exclusion of the studies not fulfilling our inclusion criteria four studies were finally analyzed. The total number of RA patients included in these studies was 4896. RESULTS: Statins were associated with reduced CV events and mortality in RA in primary prevention but not in secondary prevention. In secondary prevention after myocardial infarction (MI) there was no statistically significant difference between RA or non-RA patients either receiving atorvastatin 80 mg or simvastatin 20-40 mg daily. Treatment with atorvastatin 80 mg led to a reduction in overall risk of CV disease in both patients with and without inflammatory joint disease compared to patients receiving the conventional/low-dose statin treatment. Statin discontinuation in RA patients was associated with an increased risk of acute myocardial infarction or CV mortality. Myalgia, diarrhoea, abdominal pain and nausea may be more frequent in RA patients than in controls. CONCLUSION: The published evidence shows that in RA patients statin treatment appears to reduce CV risk in primary prevention and that statin discontinuation is associated with an increased risk for CV events. However, the significance of statin treatment in RA patients still remains unclear as only very little evidence has been published. Whether all RA patients would benefit from treatment with statins still needs to be investigated.
File Format	HTM / HTML
ISSN	17561841
Issue Number	6
Volume Number	17
e-ISSN	1756185X
Journal	International Journal of Rheumatic Diseases
Language	English
Publisher	Wiley
Publisher Date	2014-07-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Rheumatology Antirheumatic Agents Therapeutic Use Arthritis, Rheumatoid Drug Therapy Cardiovascular Diseases Prevention & Control Dyslipidemias Hydroxymethylglutaryl-coa Reductase Inhibitors Diagnosis Epidemiology Humans Patient Selection Risk Assessment Risk Factors Treatment Outcome Journal Article Review
Content Type	Text
Resource Type	Article
Subject	Rheumatology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in