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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Iwaszkiewicz, Cezary Puszczewicz, Mariusz Bialkowska-Puszczewicz, Grazyna |
| Spatial Coverage | Poland |
| Description | Country affiliation: Poland Author Affiliation: Iwaszkiewicz C ( Department of Rheumatology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.) |
| Abstract | AIM: To evaluate the prevalence and diagnostic significance of the autoantibody against citrullinated vimentin (anti-Sa) compared with the widely used anti-cyclic citrullinated peptide autoantibody (anti-CCP) in patients with rheumatoid arthritis (RA). METHOD: One hundred and sixty-nine patients hospitalized at the Department of Rheumatology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland, were enrolled in a cross-sectional study and divided into two groups. The RA group comprised 41 patients diagnosed as having RA. The non-RA control group included 128 individuals with a variety of rheumatic disorders. Serum anti-Sa and anti-CCP measurements were performed by enzyme-linked immunosorbent assay. RESULTS: The sensitivity and specificity of anti-Sa for the diagnosis of RA was 36.6% and 96.9%, respectively. For the anti-CCP test, the sensitivity was 65.9% and the specificity was 95.3%. Concomitant presence of anti-Sa and anti-CCP was determined in 36.6% of the patients with RA, whereas isolated positivity of anti-Sa was not observed. Anti-Sa positive RA patients had significantly higher anti-CCP levels compared to anti-Sa negative subjects (P < 0.05). CONCLUSION: With regard to the relatively low diagnostic sensitivity and the lack of cases identified by anti-Sa alone, we were unable to demonstrate any additional diagnostic value of the anti-Sa autoantibody in comparison to the anti-CCP autoantibody. To the authors' best knowledge, this is the first study among Polish patients verifying the clinical utility of anti-Sa in the diagnosis of RA. |
| File Format | HTM / HTML |
| ISSN | 17561841 |
| Issue Number | 1 |
| Volume Number | 18 |
| e-ISSN | 1756185X |
| Journal | International Journal of Rheumatic Diseases |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Rheumatology Antibodies, Antinuclear Blood Arthritis, Rheumatoid Diagnosis Peptides, Cyclic Immunology Adolescent Adult Aged Drug Therapy Biological Markers Case-control Studies Cross-sectional Studies Enzyme-linked Immunosorbent Assay Female Humans Male Middle Aged Poland Predictive Value Of Tests Prognosis Young Adult Comparative Study Evaluation Studies Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rheumatology |
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