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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lo, Hsiu-Jung Chu, Wen-Li Liou, Ci-Hong Huang, Szu-Hsuan Khoo, Kay-Hooi Yang, Yun-Liang |
| Description | Country affiliation: Taiwan Author Affiliation: Lo HJ ( National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan); Chu WL ( National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.); Liou CH ( National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.); Huang SH ( National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.); Khoo KH ( Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.); Yang YL ( Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan) |
| Abstract | Ndt80p, a known transcriptional factor, regulates various targets involved in stress responses, filamentous growth, and virulence in Candida albicans. Potential targets of Ndt80p have been identified at the transcriptional level. The present study was conducted to identify genes regulated by Ndt80p from the protein level. We found that the levels of Ahp1p, Fma1p, Hsp21p, Rfa2p, Snz1p, Sod1p, Sou1p, Trp99p, orf19.251, orf19.1862, and orf19.5620, were affected by the null mutation of NDT80 by two-dimensional polyacrylamide gel-electrophoresis analysis. Among the 11 proteins, all but Sou1p and Rfa2p are suggested to be involved in known functions of Ndt80p. Here, we demonstrate that Ndt80p plays a role in l-sorbose utilization through regulating SOU1 in C. albicans. |
| File Format | HTM / HTML |
| ISSN | 14384221 |
| Issue Number | 1 |
| Volume Number | 305 |
| e-ISSN | 16180607 |
| Journal | International Journal of Medical Microbiology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology Candida Albicans Genetics Metabolism Fungal Proteins Gene Expression Regulation, Fungal Sorbose Electrophoresis, Gel, Two-dimensional Gene Knockout Techniques Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology Microbiology (medical) |
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