NDLI: The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt.

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The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt.

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The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lopes, Bruno Silvester Al-Agamy, Mohamed H. Ismail, Muhammad A. Shibl, Atef M. Al-Qahtani, Ahmed A. Al-Ahdal, Mohammed N. Forbes, Ken J.
Spatial Coverage	Egypt Saudi Arabia
Description	Author Affiliation: Lopes BS ( Medical Microbiology, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address: bruno.lopes@abdn.ac.uk.); Al-Agamy MH ( College of Pharmacy, King Saud University, 11451 Riyadh 2457, Saudi Arabia); Ismail MA ( Medical Microbiology, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK.); Shibl AM ( College of Pharmacy, King Saud University, 11451 Riyadh 2457, Saudi Arabia); Al-Qahtani AA ( Department of Infection and Immunity, King Faisal Specialist Hospital & Research Center, Riyadh 11211, Saudi Arabia); Al-Ahdal MN ( Department of Infection and Immunity, King Faisal Specialist Hospital & Research Center, Riyadh 11211, Saudi Arabia); Forbes KJ ( Medical Microbiology, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK.)
Abstract	Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide including Saudi Arabia and Egypt. We examined 64, non-repetitive, Acinetobacter baumannii isolates collected in 2013 and 2014 from four different medical centres (two from Saudi Arabia and two from Egypt). All the isolates were resistant to ceftazidime and ciprofloxacin. The intI1 harbouring blaGES-11 and aac-6'-1b was detected in 19% (n=12) of the isolates. ISAba1 over-expression of blaADC gene was observed in 65% (n=42) of isolates. Of all the isolates 19% (n=12) had ISAba1 upstream of the blaOXA-51-like gene, 69% (n=44) carried the blaOXA-23 gene within the Tn2006 structure, 8% (n=5) had blaOXA-24-like gene and 9% (n=6) harboured either blaVIM-2 or blaNDM-1 gene. Eighty nine percent (n=57) of isolates were resistant to imipenem and had an MIC of ≥8mg/L. Pulsed-field gel electrophoresis (PFGE) typing revealed the presence of 23 different PFGE. Three PFGE types were very widespread, ST236 (CC104) (PFGE type 1, n=15), ST208 (CC92) (PFGE type 2, n=10), ST884 (CC unassigned) (PFGE type 3, n=7) in and across all four medical centres. The blaOXA-23 gene was found to be present on a 60kb transferable plasmid in both PFGE type 1 and 2 but was absent in PFGE type 3. This is the first study to report on the emergence of ST236 in Saudi Arabia and Egypt, and spread of distinct carbapenem resistant A. baumannii clones belonging to ST884, ST945 and ST1096 in Saudi Arabia.
File Format	HTM / HTML
ISSN	14384221
Issue Number	6
Volume Number	305
e-ISSN	16180607
Journal	International Journal of Medical Microbiology
Language	English
Publisher	Elsevier
Publisher Date	2015-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Microbiology Acinetobacter Baumannii Genetics Isolation & Purification Bacterial Proteins Drug Resistance, Multiple, Bacterial Gene Expression Regulation, Bacterial Genes, Bacterial Metabolism Carbapenems Pharmacology Ceftazidime Egypt Electrophoresis, Gel, Pulsed-field Imipenem Microbial Sensitivity Tests Molecular Sequence Data Multilocus Sequence Typing Plasmids Saudi Arabia Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Microbiology Microbiology (medical)

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