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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Drechsler-Hake, Doreen Alamir, Hanin Hahn, Julia Günter, Manina Wagner, Samuel Schütz, Monika Bohn, Erwin Schenke-Layland, Katja Pisano, Fabio Dersch, Petra Autenrieth, Ingo B. Autenrieth, Stella E. |
| Description | Country affiliation: Germany Author Affiliation: Drechsler-Hake D ( Interfaculty Institute for Cell Biology, University of Tübingen, 72076 Tübingen, Germany); Alamir H ( Department of Internal Medicine II, University of Tübingen, 72076 Tübingen, Germany.); Hahn J ( Department of Internal Medicine II, University of Tübingen, 72076 Tübingen, Germany.); Günter M ( Interfaculty Institute for Cell Biology, University of Tübingen, 72076 Tübingen, Germany); Wagner S ( Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Germany); Schütz M ( Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Germany); Bohn E ( Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Germany.); Schenke-Layland K ( Department of Woman's Health, University of Tübingen, 72076 Tübingen, Germany.); Pisano F ( Department Molecular Infection Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.); Dersch P ( Department Molecular Infection Biology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.); Autenrieth IB ( Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, 72076 Tübingen, Germany); Autenrieth SE ( Interfaculty Institute for Cell Biology, University of Tübingen, 72076 Tübingen, Germany) |
| Abstract | Enteropathogenic Yersinia enterocolitica (Ye) enters the host via contaminated food. After colonisation of the small intestine Ye invades the Peyer's patches (PPs) via M cells and disseminates to the mesenteric lymph nodes (MLNs), spleen and liver. Whether Ye uses other invasion routes and which pathogenicity factors are required remains elusive. Oral infection of lymphotoxin-ß-receptor deficient mice lacking PPs and MLNs with Ye revealed similar bacterial load in the spleen 1h post infection as wild-type mice, demonstrating a PP-independent dissemination route for Ye. Immunohistological analysis of the small intestine revealed Ye in close contact with mononuclear phagocytes (MPs), specifically CX3CR1(+) monocyte-derived cells (MCs) as well as CD103(+) dendritic cells (DCs). This finding was confirmed by flow cytometry and imaging flow cytometry analysis of lamina propria (LP) leukocytes showing CD103(+) DCs and MCs with intracellular Ye. Uptake of Ye by LP CD103(+) DCs and MCs was dependent on the pathogenicity factor invasin, whereas the adhesin YadA was dispensable as demonstrated by Ye deletion mutants. Furthermore, Ye were found exclusively associated with CD103(+) DCs in the MLNs from wild-type mice, but not from CCR7(-/-) mice, demonstrating a CCR7 dependent transport of Ye by CD103(+) DCs from LP to the MLNs. In contrast, dissemination of Ye to the spleen was dependent on MCs as significantly less Ye could be recovered from the spleen of CX3CR1(GFP/GFP) mice compared to wild-type mice. Altogether, MCs and CD103(+) DCs contribute to immediate invasion and dissemination of Ye. This together with data from other bacteria suggests MPs as general pathogenic entry site in the intestine. |
| File Format | HTM / HTML |
| ISSN | 14384221 |
| Issue Number | 6 |
| Journal | International Journal of Medical Microbiology |
| Volume Number | 306 |
| e-ISSN | 16180607 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Microbiology Microbiology (medical) |
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