NDLI: Protective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in rats.

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Protective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in rats.

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Protective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ciftci, Osman Ozdemir, Ilknur
Description	Country affiliation: Turkey Author Affiliation: Ciftci O ( University of Inonu, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Malatya, Turkey. osmciftci@gmail.com)
Abstract	The aim of this study is to investigate the effects of the quercetin (Q) and chrysin (CH) on oxidative stress, cytokines levels and body weights in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into six equal groups. TCDD, Q and CH were administered by gavages dissolved in corn oil at the doses of 2 µg/kg/week, 20 mg/kg/day and 50 mg/kg/day, respectively. The blood samples were taken from all rats at 60th days to be analyzed for the determination of thiobarbituric acid reactive substances (TBARS), tumor necrosis factor- (TNF- ) and interferon-Î³ (IFN-Î³). The results indicated that although TCDD increased significantly TBARS and TNF- levels, it caused a decline in the levels of IFN-Î³ and body weight. In contrast, these effects of TCDD on TBARS, TNF- , IFN-Î³ levels and body weight were significantly prevented by treatments of Q and CH. In conclusion, it was determined that TCDD caused the adverse effects on immune functions, body weight and oxidative stress in rats. However, Q and CH administered with TCDD eliminated these adverse effects. These results suggest that Q and CH may play a protective role against TCDD toxicity.
File Format	HTM / HTML
ISSN	08923973
Issue Number	3
Volume Number	33
e-ISSN	15322513
Journal	Immunopharmacology and Immunotoxicology
Language	English
Publisher	Taylor & Francis
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Immunology Discipline Toxicology Discipline Pharmacology Flavonoids Pharmacology Interferon-gamma Biosynthesis Oxidative Stress Drug Effects Toxicity Quercetin Thiobarbituric Acid Reactive Substances Metabolism Tumor Necrosis Factor-alpha Animals Body Weight Blood Male Rats Rats, Wistar Journal Article
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Toxicology Pharmacology Immunology

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