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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | El Morsy, Engy M. Kamel, Rehab Ahmed, Maha A. E. |
| Description | Author Affiliation: El Morsy EM ( Department of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University , Ein Helwan, Cairo , Egypt and.) |
| Abstract | CONTEXT: Ulcerative colitis is a chronic inflammatory bowel disease. Recent studies reported a pivotal role of elevated intracellular calcium in this disorder. Coenzyme Q10 (CoQ10) and amlodipine are known to maintain cellular energy, decrease intracellular calcium concentration in addition to their antioxidant and anti-inflammatory properties. OBJECTIVE: The aim of this study was to evaluate the possible protective effects of CoQ10, amlodipine and their combination on ulcerative colitis. MATERIALS AND METHODS: Colitis was induced in rats by intracolonic injection of 3% acetic acid. CoQ10 (10 mg/kg), amlodipine (3 mg/kg) and their combination were administered for 8 consecutive days before induction of colitis. RESULTS: Our results showed that administration of CoQ10, amlodipine and their combination decreased colon tissue malondialdehyde (MDA), tumor necrosis factor- (TNF- ), interleukin-1ß (IL-1ß), prostaglandin E2 (PGE2), myeloperoxidase (MPO) and heat shock protein (HSP70) levels induced by intracolonic injection of acetic acid and restored many of the colon structure in histological examination. On the other hand, they increased superoxide dismutase (SOD) activity, adenosine-5'-triphosphate (ATP) and interleukin-10 (IL-10) colonic contents. DISCUSSION AND CONCLUSION: Administration of either CoQ10 or amlodipine was found to protect against acetic acid-induced colitis. Moreover, their combination was more effective than individual administration of either of them. The protective effect of CoQ10 and amlodipine may be in part via their antioxidant, anti-inflammatory and energy restoration properties. |
| File Format | HTM / HTML |
| ISSN | 08923973 |
| Issue Number | 3 |
| Volume Number | 37 |
| e-ISSN | 15322513 |
| Journal | Immunopharmacology and Immunotoxicology |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Immunology Discipline Toxicology Discipline Pharmacology Amlodipine Pharmacology Colitis, Ulcerative Drug Therapy Colon Immunology Energy Metabolism Drug Effects Ubiquinone Analogs & Derivatives Animals Anti-inflammatory Agents Antioxidants Chemically Induced Pathology Dinoprostone Disease Models, Animal Interleukin-1beta Male Malondialdehyde Peroxidase Rats Rats, Sprague-dawley Tumor Necrosis Factor-alpha Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Toxicology Pharmacology Immunology |
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