NDLI: Localization of folate metabolic enzymes, methionine synthase and 5,10-methylenetetrahydrofolate reductase in human placenta.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shin, Jung-A Kim, Young-Ju Park, Hyesook Kim, Hee-Kyoung Lee, Hwa-Young
Description	Author Affiliation: Shin JA ( Department of Anatomy, School of Medicine, Ewha Womans University, Seoul, Korea.)
Abstract	BACKGROUND: Normal fetal development requires adequate folate levels during pregnancy. Although folate metabolic enzymes have important roles in the maintenance of normal fetal development, the location of folate metabolic enzymes, methionine synthase (MTR) and 5,10-methylenetetrahydrofolate reductase (MTHFR), has not been previously examined. METHODS: We investigated the expression of MTR and MTHFR in human term placenta obtained from normal and pregnancy-induced hypertension (PIH) patients. RESULTS: MTR is expressed in the villous syncytiotrophoblast and MTHFR is expressed in the extravillous trophoblast. There was no difference in the quantity and location of these enzymes between control and PIH patients. CONCLUSION: These results suggest that MTR in the villous trophoblast participates in the metabolism of homocysteine by using folate, and MTHFR in the extravillous trophoblast is associated with extratrophoblast invasion.
File Format	HTM / HTML
ISSN	03787346
Issue Number	4
Volume Number	78
e-ISSN	1423002X
Journal	Gynecologic and Obstetric Investigation
Language	English
Publisher	Karger
Publisher Date	2014-01-01
Publisher Place	Switzerland
Access Restriction	Subscribed
Subject Keyword	Discipline Obstetrics Discipline Gynecology 5-methyltetrahydrofolate-homocysteine S-methyltransferase Analysis Hypertension, Pregnancy-induced Enzymology Methylenetetrahydrofolate Reductase (nadph2) Placenta Genetics Metabolism Blotting, Western Female Folic Acid Gestational Age Homocysteine Humans Immunohistochemistry Pregnancy Rna, Messenger Trophoblasts Physiology Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Reproductive Medicine Obstetrics and Gynecology

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