NDLI: Prion protein gene (PRNP) polymorphisms in native Chinese cattle.

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Prion protein gene (PRNP) polymorphisms in native Chinese cattle.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Hui Wang, Xiao-Yan Zou, Wei Zhang, Ya-Ping
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Zhao H ( Laboratory for Conservation and Utilization of Bioresource, Yunnan University, Kunming, China.)
Abstract	Polymorphisms in four regions of the bovine prion protein gene (PRNP) confer susceptibility to bovine spongiform encephalopathy (BSE). These polymorphisms include a 23-bp insertion/deletion (indel) in the promoter region, a 12-bp indel in intron 1, an octapeptide repeat or 24-bp indel in the open reading frame, and a single nucleotide polymorphism (SNP) in the coding region. In this study, we investigated the frequency distributions of genotypes, alleles, and haplotypes at these indel sites in 349 native Chinese cattle and sequence variants in 50 samples. Our results showed that cattle in southern China have low frequencies of the 12-bp deletion allele and the 23-bp deletion / 12-bp deletion haplotype, which have been suggested to be relevant to BSE susceptibility. Interestingly, a significant difference was observed between BSE-affected cattle and healthy Chinese cattle in the 12-bp indel polymorphism. A total of 14 SNPs were discovered in the coding region of PRNP in Chinese cattle. Three of these SNPs were associated with amino acid changes (K3T, P54S, and S154N). The E211K substitution that was recently reported in the US atypical BSE case was not detected in this study.
File Format	HTM / HTML
ISSN	08312796
e-ISSN	14803321
Journal	Genome
Issue Number	2
Volume Number	53
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2010-02-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Genetics Genetics Polymorphism, Genetic Prions Alleles Animals Gene Deletion Gene Frequency Genotype Haplotypes Introns Molecular Sequence Data Mutagenesis, Insertional Open Reading Frames Polymorphism, Single Nucleotide Promoter Regions, Genetic Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology Biotechnology

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Structure and polymorphism of the mouse prion protein gene.

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