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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Willen, Christi M. McGwin, Gerald Liu, Bin Owsley, Cynthia Rosenstiel, Carol |
| Description | Country affiliation: United States Author Affiliation: Willen CM ( Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-0009, USA. cwillen@uab.edu) |
| Abstract | PURPOSE: To assess the efficacy of cyclosporine 0.05% ophthalmic emulsion (Restasis; Allergan, Inc., Irvine, CA) in the treatment of contact lens wearers with dry eyes. METHODS: Contact lens wearers citing dry eye problems were identified through chart review. Participants were randomly assigned to a treatment group, receiving vials of cyclosporine 0.05% ophthalmic emulsion to use twice daily, or a placebo group, receiving vials of rewetting drops (Refresh Preservative Free Artificial Tears; Allergan, Inc.) to use twice daily. Corneal staining, tear film breakup time, and Schirmer test results were documented at baseline and after 3 months. Participants also completed questionnaires, the Ocular Surface Disease Index, and the National Eye Institute Refractive Error Quality of Life Instrument at baseline and after 3 months. RESULTS: For all parameters, including objective findings and subjective reporting of symptoms, there was no statistically significant difference between the treatment and placebo groups. CONCLUSIONS: This study did not detect a beneficial effect in using cyclosporine 0.05% ophthalmic emulsion over rewetting drops for contact lens wearers. This may be attributable to the small sample size. It is also possible that the mechanism of the dry eye state in contact lens wearers may be different from that of other dry eye states and thus make cyclosporine 0.05% ophthalmic emulsion an ineffective treatment. |
| File Format | HTM / HTML |
| ISSN | 15422321 |
| Issue Number | 1 |
| Volume Number | 34 |
| e-ISSN | 1542233X |
| Journal | Eye & Contact Lens: Science & Clinical Practice |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2008-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Ophthalmology Contact Lenses Cyclosporine Administration & Dosage Dry Eye Syndromes Therapy Immunosuppressive Agents Adult Dose-response Relationship, Drug Double-blind Method Emulsions Female Follow-up Studies Humans Male Ophthalmic Solutions Quality Of Life Treatment Outcome Comparative Study Journal Article Randomized Controlled Trial Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
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