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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hammerness, Paul G. Karampahtsis, Chris Babalola, Ronke Alexander, Mark E. |
| Description | Country affiliation: United States Author Affiliation: Hammerness PG ( Harvard Medical School , Boston, MA , USA.) |
| Abstract | INTRODUCTION: This drug safety review provides an update on the long-term cardiovascular risks of therapeutic stimulant class medication for children and adults with attention-deficit/hyperactivity disorder (ADHD). AREAS COVERED: Relevant literature on the long-term (defined as ≥ 12 months) cardiovascular effects of stimulant class medications for ADHD was sought using PubMed searches for clinical literature, epidemiological reports, as well as reviews of post-marketing data and clinical guidelines/consensus statements. Comparison was made to the non-stimulant atomoxetine. EXPERT OPINION: Long-term cardiovascular risks of stimulants for healthy children and adults with ADHD are limited to minor mean elevations in blood pressure (≤ 7 mmHg) and heart rate (≤ 10 bpm). In a sizeable minority of individuals these elevations are greater and/or reach a clinical threshold. Subjective complaints may also be anticipated during long-term treatment, yet without an increase in serious cardiac outcomes above background rates per age. Future research is needed on possible latent or cumulative cardiovascular risks in healthy individuals, as well as the longer-term cardiovascular safety in vulnerable populations. |
| File Format | HTM / HTML |
| ISSN | 14740338 |
| Issue Number | 4 |
| Volume Number | 14 |
| e-ISSN | 1744764X |
| Journal | Expert Opinion on Drug Safety |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2015-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Pharmacology Attention Deficit Disorder With Hyperactivity Drug Therapy Cardiovascular Diseases Etiology Central Nervous System Stimulants Adverse Effects Adult Atomoxetine Hydrochloride Administration & Dosage Therapeutic Use Blood Pressure Drug Effects Epidemiology Child Humans Time Factors Comparative Study Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) |
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