NDLI: Weight reducing and metabolic effects of topiramate in patients with migraine--an observational study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schütt, M. Brinkhoff, J. Drenckhan, M. Lehnert, H. Sommer, C.
Description	Country affiliation: Germany Author Affiliation: Schütt M ( Department of Internal Medicine I, University of Lübeck, Lübeck, Germany. morten.schuett@uk-sh.de)
Abstract	Topiramate is an anticonvulsant agent effective in the prophylaxis of migraine, which also induces weight reduction by an unknown mechanism. We investigated the effect of topiramate on metabolic and endocrine parameters in patients with migraine independently of any intention to lose body weight. Six patients (26-61 years old, body mass indices [BMI] 20.9-32.1 kg/m(2)) with migraine were treated with an average dose of 100 mg topiramate/day over a period of 20 weeks. The following parameters were measured every 4-8 weeks: BMI, body fat proportion, waist and hip circumference, HOMA insulin resistance, fasting serum-/plasma concentrations of adiponectin, leptin, ghrelin, vascular endothelial growth factor (VEGF), cortisol, interleukin-6 and tumor necrosis factor (TNF)-alpha. Profound metabolic changes were observed for the whole treatment period. Compared with the baseline value, 20 weeks of treatment reduced the BMI by 7.2+/-1.4%, body fat proportion by 11.6+/-3.6%, waist circumference by 4.2+/-1.2%, leptin by 39.2+/-6.5% and HOMA insulin resistance by 37.3+/-5%, while adiponectin was increased by 69.9+/-17.3% (P<0.05, respectively). VEGF concentrations increased during the week 2-4 by 177.4+/-39.4% (P<0.05) followed by a continuous decrease. There were trends for a reduction in ghrelin concentration, whereas cortisol, interleukin-6 and TNF-alpha values were unchanged. In summary, in this small sample of migraine patients topiramate treatment was associated with increased insulin sensitivity, increased adiponectin concentration and a reduction of body fat in all treated patients. The role of increased VEGF concentrations prior to these metabolic changes is not clear and might, hypothetically, involve a centrally mediated effect of topiramate on body weight regulation.
File Format	HTM / HTML
ISSN	09477349
Issue Number	7
Volume Number	118
e-ISSN	14393646
Journal	Experimental and Clinical Endocrinology & Diabetes
Language	English
Publisher	Thieme
Publisher Date	2010-07-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Anti-obesity Agents Administration & Dosage Anticonvulsants Fructose Analogs & Derivatives Migraine Disorders Drug Therapy Weight Loss Drug Effects Adiponectin Blood Adipose Tissue Adult Body Mass Index Cytokines Female Hip Humans Insulin Resistance Leptin Male Middle Aged Prospective Studies Vascular Endothelial Growth Factors Waist Circumference Journal Article
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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