NDLI: Pulse pressure and systolic blood pressure are powerful independent predictors of cardiovascular disease in diabetic adults: results of an 8.4 years follow-up of Tehran Lipid and Glucose Study (TLGS).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hadaegh, F. Hatami, M. Sheikholeslami, F. Azizi, F.
Spatial Coverage	Iran
Description	Country affiliation: Iran Author Affiliation: Hadaegh F ( Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Yaman street, Velenjak, Tehran, Iran. fzhadaegh@endocrine.ac.ir)
Abstract	AIM: To determine the role of different blood pressure (BP) components as predictors of cardiovascular disease (CVD) in diabetic patients. METHODS: We followed 828 diabetic patients, aged ≥30 years, without baseline CVD and not taking antihypertensive drugs. The hazard ratios (HRs) for CVD were calculated for a 1 standard deviation (SD) change in each BP measure using Cox proportional regression analysis. RESULTS: During median 8.4 year- follow up, 134 CVD events occurred. Systolic BP (SBP), pulse pressure (PP) and mean arterial pressure (MAP) were independent predictors of CVD with multivariate adjusted hazard ratios (HRs) of 1.35, 1.36 and 1.23 respectively (all p<0.05) and similar discriminatory power (C statistics ≈75%). The multivariate models containing MAP plus one other BP component highlighted the significant improvement in the goodness of fit to predict incident CVD (likelihood ratio test =0.01); however this was not so for SBP and PP. In the elderly subjects, only PP and SBP were significantly associated with CVD. CONCLUSION: The SBP and PP are significant independent predictors of CVD in all diabetic populations (including younger and elder groups) and other BP components did not add to these measures in risk prediction.
File Format	HTM / HTML
ISSN	09477349
Issue Number	9
Volume Number	118
e-ISSN	14393646
Journal	Experimental and Clinical Endocrinology & Diabetes
Language	English
Publisher	Thieme
Publisher Date	2010-10-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Blood Pressure Physiology Cardiovascular Diseases Diagnosis Diabetes Complications Adult Aged Aged, 80 And Over Blood Glucose Analysis Metabolism Epidemiology Etiology Physiopathology Cohort Studies Female Follow-up Studies Humans Iran Lipid Metabolism Lipids Blood Male Middle Aged Predictive Value Of Tests Prognosis Systole Time Factors Evaluation Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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