NDLI: Assessment of fetal exposure and maternal elimination of perfluoroalkyl substances.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Tao Qin, Xiaolei
Description	Country affiliation: China Author Affiliation: Zhang T ( School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Sun Yat-Sen University, 135 Xingang West Street, Guangzhou 510275, China. taozhang.swiss@gmail.com.)
Abstract	In this study, we estimated the body burden (BB) of perfluoroalkyl substances (PFASs) in a fetus at the time of delivery, and elimination of PFASs in female adults during pregnancy; and explored the isomer branching pattern-related placental transfer of perfluorooctane sulfonate (PFOS). The mean BB of PFASs were 3980 ng for PFOS and 2320 ng for perfluorooctanoic acid (PFOA), therefore, the average daily exposure doses via placental transfer were estimated to be 13.7 and 8.32 ng per day for PFOS and PFOA, respectively, by dividing the BB of PFASs by gestational age. The total daily elimination of PFOS and PFOA in female adults through pregnancy was 30.1 and 11.4 ng per day, which indicates that pregnancy and child birth may reduce the PFASs levels in female adults. Further, branched PFOS was more readily transferred through the placenta than linear PFOS.
File Format	HTM / HTML
ISSN	20507887
Issue Number	8
Volume Number	16
e-ISSN	20507895
Journal	Environmental Science: Processes & Impacts
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2014-08-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Environmental Health Alkanesulfonic Acids Analysis Environmental Pollutants Fetus Metabolism Fluorocarbons Maternal Exposure Maternal-fetal Exchange Adult Blood Female Humans Placenta Pregnancy Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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